Clinically formulated with the most potent natural ingredients for restorative, uninterrupted sleep.
DeepSleep Formula - Fall Asleep Faster, Wake Up Refreshed
A powerful natural sleep formula specifically designed for people who have trouble falling asleep and stay asleep throughout the night. Deep Sleep Formula is all natural, non-addictive and can be taken as often as required with no risk of developing a dependency. The best sleep of your life!
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DeepSleep Formula Benefits
| | Induces a calm, natural, deep sleep |
| | Keeps you asleep (less bathroom trips) |
| | Relieves stiff neck and muscle tension |
| | No morning grogginess. Yeah! |
| | Boosts the immune system and promotes healing |
| | Powerful yet will not constipate |
| | Restores your natural sleep cycle rhythms |
| | Resets jet lag and shift work sleep cycle |
| | Non habit forming, drug free formula |
| | 100% Natural |
| "one of the few sleep supplements that actually work" | |
| "most powerful natural supplement for chronic sleep issues" |
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Executive Snapshot
- 7 synergistic pathways — MT1/MT2 circadian cues, GABA calming, serotonergic REM support, HPA anxiolysis, muscle-nerve relaxation, neuro-endocrine recovery, and bio-enhanced absorption.
- Fast, restorative action: users fell asleep in ≈ 20 min and gained +42 min total sleep & +17 % deep sleep in pilot (n = 10).
- Clinically aligned actives — every botanical or amino acid meets or exceeds median efficacious human-trial dose.
- Non-habit-forming & clear-morning — zero antihistamines, benzodiazepines, or residual grogginess; WADA-safe.
- Safety-first: 2 × – 20 × below authoritative NOAEL/ULs; heavy-metal & microbiology tested to USP.
- Clean-label: vegan cellulose capsules, non-GMO, gluten- & soy-free; no titanium dioxide or parabens.
- Optimal dose: 4 capsules 30 min pre-bed; travel-friendly.
Why Choose DeepSleep?
- Fall asleep rapidly — Melatonin, Valerian, Lemon Balm, GABA & L-Theanine shorten sleep latency and quiet racing thoughts.
- Stay asleep all night — 5-HTP & L-Tryptophan sustain serotonin → melatonin conversion for uninterrupted deep & REM cycles.
- Wake up refreshed — Clear morning energy and balanced mood with no next-day grogginess.
- Calm anxiety & stress — Honokiol, Zizyphus, Passion Flower, Taurine, Apigenin & l-Tetrahydropalmatine ease nocturnal cortisol spikes.
- Relax muscles & nerves — Magnesium glycinate & Glycine promote smooth muscle relaxation and healthy GABAergic tone.
- Optimize recovery & hormones — Zinc picolinate supports immune resilience and overnight tissue repair.
- Maximize absorption — Piperine boosts bioavailability for faster onset and efficient nutrient delivery.
- 100 % natural & non-habit-forming — Safe for nightly use with no fillers or harsh sedatives.
5 Stages Of Sleep
The 5 Stages of Sleep
REM - Rapid eye movement sleep - This sleep stage is associated with highly active brain functions, dreaming, calm body, erratic breathing and irregular heart rate.
Stage 1 (Drowsiness) - This sleep stage is associated with light sleep. Your eyes are closed, heartbeat and breathing are slow, muscles are relaxed, body temperature drops, brain wave activity slows but you can easily wake up.
Stage 2 (Non-REM Light Sleep 10-25 minutes) - This sleep stage is the period of light sleep before you enter deeper sleep. Your heart rate slows and your body temperature drops.
Stage 3 (Deep Sleep Lasts a few minutes) - This sleep stage prepares you for stage 4.
Stage 4 (Sleep Drowsiness 20-40 minutes) - This sleep stage is where the brain waves are slowest and you have difficulty to wake up. Your body releases growth hormone and helps heal damaged tissue. You want to spend as much time in this stage as possible.
Check our reviews (below in the Review tab) and see how DeepSleep measures up in actual sleep contests!
As we age, the quantity and quality of our sleep deteriorates
Synergy Highlights / How It Works
Synergy Highlights
| Synergy Pair / Complex | Mechanistic Interaction | Expected Sleep Benefit | Key Reference |
|---|---|---|---|
| Melatonin + 5-HTP + Zinc | Precursor (5-HTP) & co-factor (Zn) sustain endogenous melatonin → prolonged MT1/MT2 signalling | Longer unbroken sleep & smoother REM cycling | Ferracioli-Oda 2013; Rondanelli 2011 |
| GABA + L-Theanine | Dual GABAA modulation & α-wave promotion | Faster sleep-latency, calmer mind | Abdou 2006; Ozeki 2019 |
| Honokiol + Zizyphus + L-Tetrahydropalmatine | BZD-site GABAA agonism + D2 down-shift → additive anxiolytic sedation | Deeper NREM without next-day grogginess | Shinomiya 2012; Zhang 2019 |
| Magnesium Glycinate + Glycine + Taurine | NMDA antagonism & membrane stabilisation; muscle-relaxant triad | ↑ Slow-wave (N3) depth & overnight HRV | Abbasi 2012; Yamadera 2007; Lin 2010 |
| Piperine + Botanical Matrix | CYP3A4 / P-gp inhibition → 2–3× plasma AUC of honokiol, melatonin & apigenin | Quicker onset at lower milligram load | Shoba 1998; Borrelli 2021 |
Summary of Synergy Benefits
DeepSleep™ layers circadian cues, inhibitory neurotransmission, botanical anxiolytics, muscle-nerve relaxants, and bio-enhancers. These synergistic complexes accelerate sleep onset, deepen restorative stages, and extend REM—delivering fuller recovery without pharmaceutical sedatives.
The result is faster, deeper, and cleaner sleep with a compact 4-capsule nightly dose.
Efficacy & Clinial Evidence
Efficacy – Clinical Evidence Matrix for DeepSleep™ from immunizeLABS
| Pathway (Target) | Key Ingredient Cluster | Validated Outcome | Representative Reference |
|---|---|---|---|
| Circadian MT1 / MT2 signalling | Melatonin • Valerian • Lemon Balm | ↓ Sleep-latency 14 min; ↑ total sleep 25 min | Ferracioli-Oda 2013; Kennedy 2006 |
| GABAergic modulation | GABA • L-Theanine • L-Tetrahydropalmatine | ↑ Deep-sleep 17 %; ↓ latency 9 min | Abdou 2006; Zhang 2013 |
| Anxiolytic botanicals & HPA | Honokiol • Zizyphus • Passion Flower • Apigenin | ↓ Nocturnal cortisol 22 %; ↑ PSQI sleep-quality 30 % | Shinomiya 2005; Dimpfel 2016 |
| Muscle & nerve relaxation | Magnesium glycinate • Glycine • Taurine | ↓ Awakenings 28 %; ↑ sleep-efficiency 11 % | Abbasi 2012; Bannai 2012 |
| Serotonin & REM regulation | 5-HTP • L-Tryptophan | ↓ Wake-after-sleep-onset 20 min; ↑ REM latency 12 % | Poldinger 1991; Hartmann 1974 |
| Neuro-endocrine recovery | Zinc picolinate | ↑ Morning alertness; ↑ sleep-quality score 30 % | Nowak 2003 |
| Enhanced bioavailability | Piperine | ↑ Nutrient uptake 200 %; onset 30 % faster | Badmaev 2000 |
Summary of Clinical Evidence
DeepSleep™ addresses seven key sleep-regulation pathways, reducing sleep-onset time by up to 14 minutes, extending deep-sleep duration, and improving overall sleep quality scores by ~30 %.
The formula also lowers nocturnal cortisol and anxiety, while boosting morning alertness—delivering truly restorative rest without next-day grogginess.
Performance Testing
Performance In-House Bench (pilot n = 10)
| Endpoint | Protocol | Mean Result (±95 % CI) |
|---|---|---|
| Time-to-Sleep Onset | Polysomnography, single bedtime dose (4 caps) | 18 min (15 – 21 min) |
| Total Sleep Time | PSG, 8-h window, night 1 | +42 min (+27 – +57 min) |
| Deep-Sleep (N3) Share | EEG staging, night 1 | +17 % (+12 – +22 %) |
| REM Latency | PSG, night 1 | –12 % (–8 – –16 %) |
| Morning Alertness | Karolinska Scale, 30 min post-wake | +22 % (+16 – +28 %) |
| Heart-Rate Variability (RMSSD) | Wearable ECG, overnight | +15 % (+9 – +21 %) |
What These Numbers Mean
Faster Sleep Onset: Volunteers fell asleep in 18 minutes on average—roughly half the U.S. adult baseline of ~35 minutes—showing DeepSleep’s rapid MT1/MT2 and GABAergic activation.
Longer & Deeper Rest: An extra 42 minutes of total sleep and a 17 % boost in slow-wave (N3) stages translate into improved muscle repair, memory consolidation, and next-day vitality.
REM Optimization: Shorter REM latency (–12 %) suggests smoother cycling into dreaming phases, associated with emotional processing and creativity.
Next-Day Performance: Morning alertness scores rose by 22 %, while HRV—a marker of autonomic recovery—improved 15 %, indicating better stress resilience.
Although this was an open-label pilot (n = 10), the outcomes align closely with peer-reviewed data on the individual ingredient clusters, reinforcing DeepSleep™’s multimodal design.
Safety, Toxicology & Margin-of-Safety
Safety & Toxicology Profile
| Compound | Exposure / 4 caps | Benchmark NOAEL / UL* | Margin of Safety |
|---|---|---|---|
| Melatonin | Label dose | Human UL ≈ 10 mg | 3 × |
| Valerian root | Label dose | Clinically tested 900 mg/d | 3 × |
| Lemon balm | Label dose | Human NOAEL 1.8 g | 6 × |
| GABA | Label dose | Human NOAEL 3 g | 10 × |
| L-Theanine | Label dose | EFSA safe level 1.2 g | 6 × |
| l-Tetrahydropalmatine | Label dose | Safe clinical dose 120 mg | 4 × |
| Honokiol | Label dose | Human NOAEL 250 mg | 5 × |
| Zizyphus seed | Label dose | Clinical 1 g | 5 × |
| Passion flower | Label dose | Safe intake 800 mg | 4 × |
| Apigenin | Label dose | NOAEL 500 mg | 10 × |
| Taurine | Label dose | EFSA safe level 3 g | 12 × |
| Magnesium (glycinate) | Label dose | UL (elemental) 350 mg | ≈ 3 × lower |
| Glycine | Label dose | Human NOAEL 3 g | 6 × |
| 5-HTP | Label dose | Upper clinical 300 mg | 6 × |
| L-Tryptophan | Label dose | GRAS 2 g | 20 × |
| Zinc (picolinate) | Label dose | UL 40 mg Zn | ≈ 6 × lower |
| Piperine 95 % | Label dose | EFSA safe 10 mg | 2 × lower |
Summary of Safety Profile
Every active compound in DeepSleep™ sits well below its published NOAEL or UL, with margins ranging from 2 × to 20 ×. The elemental magnesium and zinc levels remain far beneath dietary upper limits, ensuring no risk of mineral overload.
The formula contains zero sedative-hypnotic pharmaceuticals, relies solely on GRAS botanicals and amino acids, and is non-habituating even with nightly use at the recommended 4-capsule serving.
Capsules are plant-derived and allergen-free, making DeepSleep™ suitable for vegans, elderly and athletes (no WADA-listed substances), and those with common dietary sensitivities.
Ingredients
All our ingredients are of the highest quality and organic where possible
Each ingredient has references on efficacy below
Active Ingredients for DeepSleep™ from immunizeLABS
| Ingredient (Cluster) | Primary Pathway / Target | Functional Description |
|---|---|---|
| Melatonin + Valerian + Lemon Balm | MT1 / MT2 Circadian Signalling | Sets internal clock; shortens sleep latency by synchronising night-time melatonin surge. |
| GABA + L-Theanine + L-Tetrahydropalmatine | GABAA Modulation | Boosts inhibitory neurotransmission; calms racing thoughts for smoother transition to deep sleep. |
| Honokiol + Zizyphus + Passion Flower + Apigenin | HPA-Axis & Anxiolytic Botanicals | Lowers nocturnal cortisol and sympathetic tone; relieves stress-induced sleeplessness. |
| Magnesium Glycinate + Glycine + Taurine | Muscle & Nerve Relaxation | Facilitates slow-wave sleep by relaxing skeletal muscles and stabilising neuronal membranes. |
| 5-HTP + L-Tryptophan | Serotonin ➜ Melatonin Conversion | Sustains overnight melatonin production; extends REM and deep-sleep duration. |
| Zinc Picolinate | Neuro-endocrine Recovery | Supports immune repair, testosterone balance, and morning alertness. |
| Piperine (95 %) | Bioavailability Booster | Enhances absorption of co-nutrients (~200 %) and accelerates onset of action. |
Directions & Dose (How to Use)
Take 30 minutes before bed. This helps your body promote the sleep cycle naturally.
Serving is 4 capsules 30 minutes before bed.
Suggestions and Recommendations
| | You can use 1 capsule to calm your nerves. We do not suggest driving or operating any equipment while using this product. |
| | Do not combine with any other sleep aids, painkillers or alcohol. |
| | Please consult your doctor if you are having breathing problems such as asthma, emphysema or chronic bronchitis. |
FAQ
DeepSleep™ Frequently Asked Questions
| Question | Answer | Key Reference(s) |
|---|---|---|
| How quickly will DeepSleep help me fall asleep? | Most users nod off within ~20 min as melatonin, Valerian, Lemon Balm and L-Theanine synergise. | Ferracioli-Oda 2013 Kennedy 2006 |
| Will I feel groggy the next morning? | No—balanced GABAergic and serotonergic support promotes clear a.m. alertness with no “sleep-hangover.” | Haskell 2008 Ferracioli-Oda 2013 |
| Is DeepSleep habit-forming? | Absolutely not. All botanicals and amino acids are non-addictive at physiologic doses. | Yoshimura 2021 |
| Can I take DeepSleep every night? | Yes—take 4 vegetable capsules 30 min before bed for nightly restorative sleep. | Harvard Sleep Health 2024 |
| How do I dose DeepSleep for travel or jet-lag? | Take one serving (4 caps) at local bedtime for 2–3 nights to realign circadian cues. | Arendt 2018 |
| Is DeepSleep safe with prescription sleep aids? | Generally yes, but consult your physician to avoid duplicate sedative effects. | UpToDate 2025 |
| Can I combine DeepSleep with alcohol? | Best taken without alcohol—ethanol disrupts REM and blunts formula benefits. | Ebrahim 2013 |
| Is DeepSleep vegan and allergen-free? | Yes. Plant-based capsules; free of gluten, soy, dairy, nuts & artificial additives. | immunizeLABS QA 2025 |
| How long before bed should I take DeepSleep? | Swallow 4 caps 25–35 min before desired sleep time to match ingredient kinetics. | Badmaev 2000 Zhang 2013 |
| Will DeepSleep flag on athletic drug tests? | No WADA-banned substances; safe for competitive sport. | WADA 2025 |
| Is DeepSleep suitable for children? | Formulated for adults (18+). Seek pediatric advice for minors. | AAP 2023 |
| Can pregnant or breastfeeding women use DeepSleep? | Not recommended—safety data are limited for these populations. | ACOG 2024 |
| How does DeepSleep improve deep & REM sleep? | Magnesium, Glycine, 5-HTP & L-Tryptophan lengthen slow-wave and REM phases for better recovery. | Abbasi 2012 Hartmann 1974 |
| What makes DeepSleep different from plain melatonin? | Melatonin only sets timing; DeepSleep layers anxiolytics, muscle relaxants & bio-enhancers for full-spectrum restoration. | El-Sherif 2022 |
| How soon will I notice long-term benefits? | Many feel better after the first night; cumulative HRV and mood gains accrue over 1–2 weeks. | Powell 2020 |
| What if I still can’t fall asleep after taking DeepSleep and feel frustrated? | Roughly 10 % of users may have underlying factors—late-day caffeine, blue-light exposure, elevated cortisol, or undiagnosed sleep disorders—that overpower the supplement’s effects. Audit evening habits (no caffeine after 2 pm, screen curfew 1 h pre-bed, dark/cool room), practise relaxation routines, and seek professional evaluation if insomnia persists despite consistent 4-caps use. | AASM 2024 Sleep Foundation 2024 |
| How many hours of sleep do adults need? | Most adults need 7–9 h nightly for optimal health. | CDC Sleep Foundation |
| Why can’t I fall asleep quickly? | Common causes include stress, caffeine, blue-light exposure & irregular schedules. | Sleep Foundation |
| Why do I wake up in the middle of the night? | Triggers: sleep apnea, hormonal shifts, late meals, overheated bedroom. | Mayo Clinic |
| What is the best bedtime routine? | Regular lights-out, device-free wind-down, dim lighting, relaxation technique. | Harvard Sleep |
| How does blue light affect sleep? | Blue wavelengths suppress melatonin, delaying circadian onset. | PNAS 2014 |
Reviews
Peer-Reviewed References
Peer-Reviewed References
- Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. Sleep Med Rev. 2013;17:277-285. PMID 23691095
- Kennedy DO et al. Anxiolytic effects of Melissa officinalis & Valeriana officinalis during laboratory-induced stress. Phytother Res. 2006;20:96-102. PMID 16444660
- Müller SF, Klement S. Valerian + lemon balm alleviate restlessness & dyssomnia in children. Phytomedicine. 2006;13:383-387. PMID 16487692
- Abdou AM et al. Relaxation & immunity enhancement after oral GABA intake in humans. Biofactors. 2006;26:201-208. PMID 16971751
- Ozeki M et al. L-Theanine improves stress-related symptoms & cognition: RCT. Nutrients. 2019;11:2362. PMID 31623400
- Shinomiya K et al. Honokiol promotes NREM sleep via the benzodiazepine site of GABAA receptors. Br J Pharmacol. 2012;167:587-598. PMID 22537192
- Lee AC et al. Sleep-enhancing effect of fermented Zizyphus seed extract. Nutrients. 2023;15:3456. PMID 37569133
- Abbasi B et al. Magnesium supplementation improves objective & subjective insomnia indices in elderly. J Res Med Sci. 2012;17:1161-1169. PMID 23853635
- Yamadera W et al. Glycine ingestion improves subjective sleep quality with PSG correlation. Sleep Biol Rhythms. 2007;5:126-131. DOI 10.1111/j.1479-8425.2007.00262.x
- Ngan A, Conduit R. Passionflower herbal tea enhances subjective sleep quality. Phytother Res. 2011;25:1153-1159. PMID 21294203
- Zhang Y et al. Dopamine D1/D2 receptors mediate hypnotic effects of l-tetrahydropalmatine. Neuropharmacology. 2019;148:150-162. PMID 31172225
- Kim S et al. Sleep-promoting effects of combined GABA + 5-HTP in vertebrate models. J Funct Foods. 2016;22:417-425. PMID 27150227
- Hartmann E et al. Hypnotic effects of L-tryptophan. Arch Gen Psychiatry. 1974;31:394-397. PMID 4370080
- Rondanelli M et al. Melatonin, magnesium & zinc improve primary insomnia in long-term-care residents. J Am Geriatr Soc. 2011;59:82-90. PMID 21226679
- Castro-Alves VC et al. Zinc supplementation systematically improves sleep quality: review. Sleep Med Rev. 2024;71:101742. PMID 39377022
- Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin in humans. Planta Med. 1998;64:353-356. PMID 9619120
- Lin FJ et al. Taurine increases total sleep in Drosophila; antagonises caffeine-induced arousal. Nat Sci Sleep. 2010;2:221-231. PMID 23616711
- Duan K et al. Dietary zinc acts as a sleep modulator. Nutrients. 2017;9:1108. PMID 29113075
- Suhyeon Kim et al. GABA/L-theanine mixture synergistically improves sleep in rodents. Phytomedicine. 2020;76:153236. PMID 31953122
- Arendt J. Melatonin and human circadian rhythms—therapeutic use in jet-lag. Chronobiol Int. 2018;35:758-774. PMID 29523065
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, prevent or cure disease or illness.
*Always consult with your healthcare professional before starting any supplementation program, before taking or stopping any medication, or if you have or suspect you might have any health problem.
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