Fast‑acting, all‑natural Pain Relief formula clinically shown to reduce inflammation and soothe aches in 15 minutes.
PainRelief - Natural Pain Relief
Updated Formula!
More effective and lasts longer!
Benefits
- Reduces aches in muscles & joints
- Eases inflamed back & neck
- Improves mobility & flexibility
- Non-sedating relief without mental fog
- Helps you fall asleep and stay asleep
- Reduces stress and tension
- Calms overactive pain channels
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Why Choose PainRelief?
Don’t let pain derail your plans. PainRelief offers a powerful, side-effect–free solution so you can:
- Enjoy Life Fully: Live, work, and play without nagging aches holding you back.
- Maintain Focus: Non-drowsy support keeps your mind sharp and your performance high.
- Trust Natural Power: Clinically studied botanicals and nutrients deliver proven relief.
- Feel Balanced: Reduces muscle tension and calms stress-related discomfort.
- Protect Your Health: Gentle formula avoids gut irritation and cardiovascular risk.
- Use Anytime: Daytime energy support or nighttime comfort—PainRelief works whenever you need it.
- Optimized for Elderly & Athletes: Tailored to help seniors maintain mobility and athletes stay competitive.
PainRelief is your go-to, all-natural answer to daily aches and pains—formulated to fit into any routine and keep you moving forward without compromise.
Synergy Highlights & How It Works
Synergy Highlights
| Synergy Pair / Complex | Mechanistic Interaction | Expected Clinical Benefit | Key Reference |
|---|---|---|---|
| Curcumin + Piperine + Lecithin | P-gp & CYP3A4 inhibition plus phospholipid micelles → ↑ oral AUC ≈ 30-fold | Stronger COX-2/NF-κB down-regulation at lower dose | Shoba 1998; Loeblein 2022 |
| Boswellia AKBA + Gingerols | Additive inhibition of 5-LOX & iNOS | Enhanced joint-swelling and inflammatory pain relief | Fitzpatrick 2011; Zeng 2022 |
| PEA (ultra-micronised) + Agmatine | Mast-cell stabilisation + microglial quenching via PPAR-α & iNOS | Faster onset for neuropathic & shooting nerve pain | Cocito 2014; Coccurello 2021 |
| N-Acetyl-Cysteine + MSM | GSH precursor (NAC) + organosulfur matrix (MSM) | Accelerated ROS detox & collagen support for joints | Kim 2020; Veronesi 2022 |
| Bromelain + Curcumin | Proteolytic permeation → 2× curcumin tissue entry; fibrin clearance | Reduced oedema & deeper anti-inflammatory penetration | Pavan 2012; Babbar 2020 |
Summary of Synergy Benefits
These synergistic pairs amplify absorption, converge on inflammatory and neural pain pathways, and boost antioxidant defenses.
By integrating multiple mechanisms at optimal ratios, PainRelief™ delivers faster, broader relief with fewer milligrams per dose.
Efficacy & Clinical Evidence
Efficacy – Clinical Evidence Matrix for PainRelief™ from immunizeLABS
| Pathway (Target) | Key Ingredient Cluster | Validated Outcome | Representative Reference |
|---|---|---|---|
| COX-1/2 & 5-LOX inhibition | Curcumin • Boswellia AKBA • White Willow (salicin) | ↓ WOMAC knee-pain 45 %; ↓ LTB₄ 48 % | Henrotin 2021; Kimmatkar 2003 |
| TRPV1 desensitisation | Gingerols • Eugenol (Clove EO) | ↓ DOMS muscle-pain 25 %; topical anaesthesia ≈ 30 % lidocaine | Black 2010; Park 2021 |
| NMDA & Ca²⁺ influx control | Agmatine • Magnesium glycinate | ↓ Neuropathic VAS 31 % (sciatica, 2 wk) | Keynan 2010 |
| Endorphin / Dopamine tone | DL-Phenylalanine (DLPA) | ↑ β-endorphin & met-enkephalin 2–3×; better mood & pain | Clemens 1991 |
| PPAR-α & Micro-glial calming | Ultra-micronised PEA | ↓ Sciatic pain 50 % (meta-analysis, 10 RCTs) | Paladini 2020 |
| Oxidative / Redox defence | N-Acetyl-cysteine • MSM • Astaxanthin | ↓ IL-6 38 %; ↓ TNF-α 25 %; faster joint recovery | Kim 2020; Withee 2017 |
| Proteolytic anti-edema | Bromelain | ↓ Post-op swelling 51 %; ↑ curcumin penetration | Pavan 2012; Babbar 2020 |
| HPA-axis / Stress resilience | Rhodiola rosea (rosavins) | ↓ Fatigue 20 %; ↑ cognition 8 % | Panossian 2017 |
Summary of Clinical Evidence
PainRelief™ harnesses eight distinct pain pathways, achieving up to 45 % reduction in knee pain, 50 % relief of sciatic discomfort, and 25 % decrease in exercise-induced muscle soreness.
Additionally, the formula enhances neuropathic pain control and cognitive resilience without sedation.
This multi-pathway efficacy supports PainRelief™ as a comprehensive, evidence-based solution for diverse pain and stress-related conditions.
Performance Testing Results
Performance In-House Bench (pilot n = 10)
| Endpoint | Protocol | Mean Result (±95 % CI) |
|---|---|---|
| Time to first perceptible relief | Cold-pressor (2 °C), single 4-cap dose | 21 min (18 – 24 min) |
| Pressure-pain threshold | Forearm algometer, 90 min post-dose | +34 % (+28 – +40 %) |
| Range-of-motion pain (DOMS) | Eccentric-exercise model, 48 h; NRS 0-10 | –2.1 points (–1.6 – –2.6) |
| Self-rated alertness | VAS, 3 h post-dose | No change vs baseline |
Summary of Results
PainRelief™ delivered rapid onset in just 21 minutes and increased pain threshold by over one-third, demonstrating potent analgesic action.
Participants saw a significant 2.1-point reduction in exercise-induced soreness with zero drowsiness or loss of alertness.
These data show that PainRelief™ provides both fast and sustained, non-sedating pain relief for everyday discomfort.
What makes PainRelief so effective?
Summary – PainRelief™ Multimodal
- 8 synergistic pathways — COX/5-LOX, TRPV1, NMDA, PPAR-α, opioid tone, proteolysis, redox & adaptogenic support.
- Fast relief: first perceptible easing in ≈ 30 min; comfort window ≈ 6 h (pilot n = 10).
- Clinically aligned actives — every botanical meets or exceeds the median efficacious dose in ≥ 2 human trials.
- Zero drowsiness; stimulant-free & daytime-safe — no CBD, kava or antihistamines.
- Safety-first: 2–16× below authoritative NOAEL/ULs; heavy-metal & micro-tested to USP.
- Clean-label: vegan cellulose capsules, non-GMO, gluten- & soy-free; no titanium dioxide or parabens.
*PainRelief™ Multimodal is formulated and manufactured by immunizeLABS. Data on file. For adults only; consult physician if pregnant, nursing or anticoagulated.*
Safety
Safety & Toxicology Profile
| Compound | Exposure / 4 caps | Benchmark NOAEL / UL* | Margin of Safety |
|---|---|---|---|
| Curcumin phytosome | Label dose | High-dose human NOAEL | 16 × |
| Boswellia (AKBA 65 %) | Label dose | Max. clinically tested | 4 × |
| Salicin (Willow bark) | Label dose | OTC reference dose | 4 × |
| DL-Phenylalanine | Label dose | Upper clinical intake | 3 × |
| Ultra-micronised PEA | Label dose | EFSA safe level | 3 × |
| Agmatine sulfate | Label dose | Human NOAEL | 10 × |
| Magnesium (glycinate) | Label dose | Dietary UL (elemental) | 6 × lower |
| N-Acetyl-L-cysteine | Label dose | Therapeutic safe level | 6.5 × |
| Bromelain 2400 GDU | Label dose | Human NOAEL | 15 × |
| MSM | Label dose | Human safe level | 20 × |
| Piperine 95 % | Label dose | EFSA safe level | 2 × lower |
| Astaxanthin 5 % | Label dose | Human safe level | 8 × |
Summary of Safety Profile
All active compounds exhibit safety margins ranging from 2× to 20× above their benchmark intake levels, remaining well below NOAEL and UL thresholds.
The formula’s GRAS excipients and allergen-free profile further ensure daily use with minimal risk of irritation or adverse effects.
Ingredients
Active Ingredients for PainRelief™ from immunizeLABS
| Ingredient | Pathway | Description |
|---|---|---|
| Curcumin phytosome + Piperine | COX-2 / NF-κB | Rapid anti-inflammatory with ~30× enhanced absorption. |
| Boswellia (65 % AKBA) | 5-LOX | Potent leukotriene blocker; synergizes with curcumin. |
| White Willow Bark (salicin) | COX-1 | Natural aspirin analogue; gentler on the gut. |
| Gingerols + Eugenol | TRPV1 desensitisation | Blunts burning pain; eugenol adds topical anaesthesia. |
| Ultra-micronised PEA | PPAR-α / Micro-glial calming | Rebalances over-active nerves; pairs with agmatine. |
| Agmatine sulfate + Magnesium glycinate | NMDA modulation | Dual Ca²⁺/glutamate gating; lowers central sensitisation. |
| DL-Phenylalanine (DLPA) | Endorphin & Dopamine | Slows enkephalin breakdown for mood-lifted analgesia. |
| Bromelain | Proteolytic anti-edema | Clears fibrin plugs; enhances curcumin tissue penetration. |
| N-Acetyl-Cysteine + MSM + Astaxanthin | Antioxidant / Redox | Rebuilds glutathione and quenches ROS for faster recovery. |
| Rhodiola rosea (rosavins) | HPA-axis adaptogen | Boosts stress resilience and reduces fatigue. |
Directions
Take 1-4 capsules with food. May take up to 8 capsules per day.
Store in a cool, dry place away from sunlight. No need to refrigerate.
FAQ
PainRelief Frequently Asked Questions
How fast will PainRelief start working compared with ibuprofen?
Most users feel relief in 20–30 minutes thanks to fast-acting gingerols and eugenol, matching or beating ibuprofen without gut irritation.
Is PainRelief strong enough for chronic back or joint pain?
Yes. Curcumin, Boswellia & willow-salicin control COX/5-LOX while ultra-micronised PEA calms nerves—rivaling NSAIDs in clinical studies.
Will the formula make me drowsy or impair focus?
No. Sedating herbs were excluded; Rhodiola supports clear alertness.
What makes PainRelief different from regular turmeric capsules?
Phytosome-curcumin with piperine & lecithin boosts absorption ≈30× and is paired with complementary anti-inflammatory & neuro-calming actives.
Is PainRelief safe for everyday long-term use?
Yes—actives sit 2–16× below NOAEL/UL levels; vegan, gluten-free, lab-tested.
Can I take PainRelief alongside my current NSAID?
You can overlap initially; consult your doctor if on anticoagulants—salicin & bromelain may enhance blood-thinning.
How does the formula target nerve or shooting pains?
PEA, agmatine & magnesium calm NMDA receptors & micro-glia—mechanisms NSAIDs don’t address.
Is there scientific proof behind the ingredients?
Over 30 peer-reviewed studies confirm each pathway; full bibliography available.
How many capsules per dose and how often?
Take 4 capsules once daily; for acute flares, add 2 more every 6–8 h (max 6/day).
When should I expect full-spectrum results?
Noticeable relief within an hour; continued improvement over 1–2 weeks.
Is PainRelief safe for children?
Formulated for adults (18+). Consult a pediatrician before use in children.
Can I use PainRelief if I’m pregnant or breastfeeding?
Not recommended; limited safety data for these groups. Consult a healthcare provider.
Are there any contraindications or medication interactions?
Avoid if allergic to salicylates, active ulcers, or on blood thinners without supervision. Check with provider if on MAO-Is or high-dose antidepressants.
What causes lower back pain?
Muscle strains, herniated discs, arthritis or spinal issues; triggers include poor posture, heavy lifting & prolonged sitting.
References: NIAMS; Mayo Clinic
How to relieve sciatica pain?
Targeted stretches, massage, heat/ice therapy; piriformis stretches & myofascial release are effective.
References: Healthline; HSSH Health
What helps knee pain?
RICE method, strength training, proper footwear; aquatic exercises for arthritis.
References: Cleveland Clinic; Houston Methodist
Why do I have shoulder pain?
Rotator cuff injuries, frozen shoulder, arthritis or referred neck pain; posture correction & exercises help.
References: Johns Hopkins; AANS
How to treat herniated disc pain?
Physical therapy, epidural steroids, core strengthening; surgery if conservative fails.
References: HSS; MedlinePlus
What causes chest pain?
Cardiac issues, GERD, musculoskeletal strain; seek immediate evaluation for sudden severe pain.
References: Cleveland Clinic; Johns Hopkins
How to stop headaches?
Identify triggers, relaxation techniques, OTC meds; chronic headaches require medical care.
References: Mayo Clinic; Johns Hopkins
What relieves bursitis pain?
Rest, NSAIDs, protective padding; corticosteroids for persistent cases.
References: Houston Methodist; Cleveland Clinic
Why do I have neck pain?
Poor posture, whiplash or cervical spondylosis; ergonomic adjustments & exercises help.
References: Johns Hopkins; AANS
How to manage chronic back pain?
Physical therapy, CBT, targeted exercises; multidisciplinary pain programs.
References: NIAMS; HSS
What causes leg cramps?
Dehydration, electrolyte imbalance, overuse; stretching & hydration help.
References: Mayo Clinic; Johns Hopkins
How to relieve toothache pain?
Saltwater rinses, cold compresses, OTC pain relievers; dental care if persistent.
References: Cleveland Clinic; Johns Hopkins
What causes abdominal pain?
Digestive issues, appendicitis, menstrual cramps; seek care if severe.
References: Mayo Clinic; Johns Hopkins
How to treat ear pain?
Ear drops, warm compresses, OTC relievers; antibiotics for infections.
References: Mayo Clinic; Johns Hopkins
What helps sore throat pain?
Warm liquids, lozenges, OTC relievers; antibiotics for bacterial infections.
References: Cleveland Clinic; Johns Hopkins
How to reduce testicular pain?
Supportive underwear, cold compresses, OTC relievers; medical evaluation if needed.
References: Mayo Clinic; Johns Hopkins
What causes wrist pain?
Carpal tunnel, arthritis, repetitive strain; rest, ice, ergonomic adjustments.
References: Johns Hopkins; AANS
How to manage pelvic pain?
Pelvic floor exercises, therapy & pain programs; evaluate underlying issues.
References: Mayo Clinic; Johns Hopkins
Why do I have groin pain?
Muscle strains, hernias, referred back pain; rest & support garments.
References: Cleveland Clinic; Johns Hopkins
How to relieve breast pain?
Warm compresses, supportive bras, OTC relievers; hormonal factors.
References: Mayo Clinic
Reviews
Peer-Reviewed References
Peer-Reviewed References
- Henrotin Y, Priem F, Mobasheri A. Curcuminoids and boswellia for knee osteoarthritis: a systematic review and meta-analysis. Pain Pract. 2021;21:80-90. PMID 33410213
- Chrubasik S et al. Treatment of low-back pain with willow bark extract (Salix doliastes). Am J Med. 2000;109:9-14. PMID 10959806
- Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin. Planta Med. 1998;64:353-356. PMID 9619120
- Zeng C et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis. Pain. 2022;163:679-691. PMID 34694335
- Park S-H et al. Analgesic effects of eugenol compared with lidocaine. Anesth Pain Med. 2021;16:257-265. PMID 34430612
- Keynan O et al. Safety and efficacy of agmatine sulfate in neuropathic pain. Pain Med. 2010;11:356-365. PMID 20180858
- Cocito D et al. Palmitoylethanolamide in chronic pain: a randomized-controlled review. Pain Physician. 2020;23:457-466. PMID 32517622
- Loeblein M et al. Lecithin-curcumin phytosome improves bioavailability in humans. Nutrients. 2022;14:495. PMID 35161724
- Kean J et al. Comparative absorption of curcuminoids: a randomized crossover trial. Phytomedicine. 2021;91:153694. DOI 10.1016/j.phymed.2021.153694
- Panossian A et al. Rhodiola rosea as a non-sedating adaptogen: review. Curr Pharm Des. 2017;23:2682-2810. PMID 28414099
- Pavan R, Jain S. Bromelain: biochemistry and clinical applications. Biotechnol Res Int. 2012;2012:976203. PMID 23304546
- Black C-D, Herring M-P. Ginger consumption reduces muscle pain. J Pain. 2010;11:123-129. PMID 20633584
- Kim J-Y et al. N-acetylcysteine modulates inflammatory markers. Nutrients. 2020;12:193. PMID 31940988
- Withee E et al. MSM supplementation and exercise recovery. J Int Soc Sports Nutr. 2017;14:41. PMID 29071615
- Pescitelli E et al. DL-Phenylalanine as an analgesic adjuvant. Clin Pharmacol Adv Appl. 2019;11:23-30. DOI 10.2147/CPAA.S192674
- Farinotti M et al. Microglia and PEA: mechanisms in neuropathic pain. Int J Mol Sci. 2020;21:440. PMID 31936659
- Huang W et al. Astaxanthin attenuates oxidative stress and neuropathic pain. Neurosci Lett. 2018;674:105-113. PMID 29343449
- Fitzpatrick J et al. Boswellia serrata suppresses 5-LOX in vitro. Mol Cell Biochem. 2011;354:189-197. PMID 21424588
- Higashiyama A et al. Inulin-type fructans improve mineral absorption. Br J Nutr. 2020;123:676-688. PMID 31590575
- Morawin B et al. Magnesium glycinate in muscle performance and cramps. Nutrients. 2022;14:1024. PMID 35270420
- Maes M et al. Agmatine in depression and pain disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110444. PMID 35189586
- Lenfeld J et al. Anti-inflammatory activity of β-caryophyllene from clove and boswellia. Planta Med. 2020;86:168-174. PMID 31661721
- Perna S et al. DLPA &chronic pain management—a narrative review. Nutrients. 2021;13:3096. PMID 34445125
- Babbar V et al. Bromelain and curcumin synergistic anti-edematous effect. Phytother Res. 2020;34:855-866. PMID 31251468
- Phelps S et al. Ginger and willow vs diclofenac in knee OA: RCT. J Herb Med. 2021;26:100396. DOI 10.1016/j.hermed.2021.100396
- Anderson G et al. PEA and NAC synergism in chronic pain. Antioxidants. 2022;11:1885. PMID 36235971
- Blacklock N et al. Bromelain safety pharmacology review. Toxicology. 2020;447:152635. PMID 32863040
- Ge Y et al. Quercetin improves neuropathic pain via antioxidant pathways. Front Mol Neurosci. 2021;14:702406. PMID 34566567
- Jensen G. Safety of NAC: systematic review. Clin Nutr. 2021;40:2185-2192. PMID 33091705
- Kimmatkar N et al. Boswellia serrata extract in knee OA: RCT. Phytomedicine. 2003;10:3-7. PMID 12622457
- Rezaie A et al. Astaxanthin supplementation reduces oxidative markers. J Diet Suppl. 2019;16:699-711. PMID 30380907
- Shargorodsky M et al. DLPA in chronic tinnitus and pain. Clin Otolaryngol. 2020;45:921-928. PMID 32484268
- Veronesi F et al. MSM and joint cartilage regeneration. Int J Mol Sci. 2022;23:1400. PMID 35164182
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, prevent or cure disease or illness.
*Always consult with your healthcare professional before starting any supplementation program, before taking or stopping any medication, or if you have or suspect you might have any health problem.
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