DeepSleep Formula - Natural Sleep Supplement
DeepSleep Formula - Natural Sleep Supplement
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Product Reviews
New to DeepSleep? See how it works
Sleep Isn't Missing.
It's Blocked.
Your brain is stuck in survival mode.
Fix the 7 signals → sleep returns naturally.
Sleep Is a Combination Lock—
Not a Switch
All 7 signals must align. Miss one → sleep fails.
🚨 If even one signal is off… your sleep stays broken.
Why Everything You've Tried Eventually Stops Working
The "One Switch" Approach
- • Just melatonin = timing only
- • Just magnesium = muscle only
- • Just CBD = calm only
The 7-Signal System
- ✅ All 7 pathways addressed
- ✅ Clinical doses that work together
- ✅ Deep sleep + morning recovery
This isn't about making you drowsy. It's about turning all 7 signals correctly so your body can do what it's designed to do.
*Pilot data (n=10). Individual results vary.
"But I've tried everything..."
➔ "Melatonin works for $10. Why pay more?"
Melatonin is just the starter signal. It tells your brain when to sleep—but it doesn't create the conditions for deep, restorative sleep.
DeepSleep coordinates the full system:
- GABA + L-Theanine → Quiet mental chatter
- Magnesium Glycinate + Taurine → Release physical tension
- Honokiol + Apigenin → Downshift stress response
- 5-HTP + Zinc → Support sleep cycling + morning clarity
✅ Result: Users report going from 28 minutes to 2+ hours of deep sleep means: your immune system actually works again, your face stops looking exhausted, and you stop being "the tired one" everyone walks around.
➔ "What if I don't know if I have a sleep or inflammation issue?"
You don't have to guess. Test both formulas risk-free.
DeepSleep Sample
85% of people sleep better when all 7 signals align.
✔ Sample added to your cart — scroll up to checkout
PainRelief Sample
10% of people slept better where the root cause was
inflammation preventing sleep
✔ Sample added to your cart — scroll up to checkout
Turn On All 7 Signals.
You’re fixing what’s blocking your sleep.
You're Not Buying a Bottle.
You're investing in 30 nights of real recovery.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results vary. Always read label and follow directions.
Discover the Science of DeepSleep
DeepSleep™ Multimodal Scientific Compendium
Evidence-based formulation backed by 20+ Peer-Reviewed Studies Clinical Trials ISO Standards
Executive Snapshot
Multimodal Sleep Restoration, Zero Next-Day Grogginess
DeepSleep™ targets sleep through seven synergistic pathways:
- 7 synergistic pathways-
circadian rhythm support, deep calm, sleep-cycle support, calming botanical, muscle relaxation, recovery & alertness, and enhanced absorption. - Fast onset-
mean sleep latency of 18 min in pilot (n = 10) — half the adult baseline. - Clinically aligned actives-
each ingredient meets or exceeds efficacious dose in ≥ 2 human trials. - Zero next-day grogginess-
morning alertness ↑ 22 %; non-habituating — no pharmaceutical sedatives, no antihistamines, no melatonin overdose. - Safety-first-
all compounds 2–20× below NOAEL/UL; GRAS excipients; allergen-free. - Clean-label-
vegan cellulose capsules, non-GMO, gluten- & soy-free; no titanium dioxide or parabens.
*DeepSleep™ Multimodal is formulated and manufactured by immunizeLABS. Data on file. For adults only; consult physician if pregnant, nursing or managing medical conditions.*
The 5 Stages of Sleep
REM - Rapid eye movement sleep - This sleep stage is associated with highly active brain functions, dreaming, calm body, erratic breathing and irregular heart rate.
Stage 1 (Drowsiness) - Light sleep. Eyes closed, heartbeat and breathing slow, muscles relax, body temperature drops.
Stage 2 (Non-REM Light Sleep) - Period of light sleep before deeper sleep. Heart rate slows, body temperature drops.
Stage 3 (Deep Sleep) - Prepares you for stage 4, lasts a few minutes.
Stage 4 (Sleep Drowsiness) - Brain waves are slowest, difficult to wake. Body releases growth hormone, helps heal tissue. You want to spend as much time in this stage as possible.
Check our reviews (below in the Review tab) and see how DeepSleep measures up in actual sleep contests!
Synergy Highlights
| Synergy Pair / Complex | Mechanistic Interaction | Expected Sleep Benefit | Key Reference |
|---|---|---|---|
| Melatonin + 5-HTP + Zinc | Precursor (5-HTP) & co-factor (Zn) sustain endogenous melatonin → prolonged circadian signalling | Longer unbroken sleep & smoother REM cycling | Ferracioli-Oda 2013; Rondanelli 2011 |
| GABA + L-Theanine | Dual calming support & α-wave promotion | Faster sleep-latency, calmer mind | Abdou 2006; Ozeki 2019 |
| Honokiol + Zizyphus + L-Tetrahydropalmatine | GABA receptor support + calming pathways → deeper relaxation support | Deeper NREM without next-day grogginess | Shinomiya 2012; Zhang 2019 |
| Magnesium Glycinate + Glycine + Taurine | Mineral-based nerve calming & membrane support; muscle-relaxant triad | ↑ Slow-wave (N3) depth & overnight HRV | Abbasi 2012; Yamadera 2007; Lin 2010 |
| Piperine + Botanical Matrix | Enhanced absorption pathways → 2–3× plasma AUC of honokiol, melatonin & apigenin | Quicker onset at lower milligram load | Shoba 1998; Borrelli 2021 |
Summary of Synergy Benefits:
- These synergistic complexes accelerate sleep onset, deepen restorative stages, and extend REM—delivering fuller recovery without pharmaceutical sedatives.
- The result is faster, deeper, and cleaner sleep with a compact 4-capsule nightly dose.
Efficacy – Clinical Evidence Matrix
| Pathway (Target) | Key Ingredient Cluster | Validated Outcome | Representative Reference |
|---|---|---|---|
| Circadian rhythm support | Melatonin • Valerian • Lemon Balm | ↓ Sleep-latency 14 min; ↑ total sleep 25 min | Ferracioli-Oda 2013; Kennedy 2006 |
| Deep calm pathways | GABA • L-Theanine • L-Tetrahydropalmatine | ↑ Deep-sleep 17 %; ↓ latency 9 min | Abdou 2006; Zhang 2013 |
| Calming botanical support | Honokiol • Zizyphus • Passion Flower • Apigenin | ↓ Nighttime stress markers 22 %; ↑ PSQI sleep-quality 30 % | Shinomiya 2005; Dimpfel 2016 |
| Muscle & nerve relaxation | Magnesium glycinate • Glycine • Taurine | ↓ Awakenings 28 %; ↑ sleep-efficiency 11 % | Abbasi 2012; Bannai 2012 |
| Sleep cycle support | 5-HTP • L-Tryptophan | ↓ Wake-after-sleep-onset 20 min; ↑ REM latency 12 % | Poldinger 1991; Hartmann 1974 |
| Recovery & morning alertness | Zinc picolinate | ↑ Morning alertness; ↑ sleep-quality score 30 % | Nowak 2003 |
| Enhanced absorption | Piperine | ↑ Nutrient uptake 200 %; onset 30 % faster | Badmaev 2000 |
Summary of Clinical Evidence:
- DeepSleep™ addresses seven key sleep-regulation pathways, reducing sleep-onset time by up to 14 minutes, extending deep-sleep duration, and improving overall sleep quality scores by ~30 %.
- The formula also supports nighttime calm and stress reduction, while boosting morning alertness—delivering truly restorative rest without next-day grogginess.
In-House Bench Performance (pilot n = 10)
| Endpoint | Protocol | Mean Result (±95 % CI) |
|---|---|---|
| Time-to-Sleep Onset | Polysomnography, single bedtime dose (4 caps) | 18 min (15 – 21 min) |
| Total Sleep Time | PSG, 8-h window, night 1 | +42 min (+27 – +57 min) |
| Deep-Sleep (N3) Share | EEG staging, night 1 | +17 % (+12 – +22 %) |
| REM Latency | PSG, night 1 | –12 % (–8 – –16 %) |
| Morning Alertness | Karolinska Scale, 30 min post-wake | +22 % (+16 – +28 %) |
| Heart-Rate Variability (RMSSD) | Wearable ECG, overnight | +15 % (+9 – +21 %) |
What These Numbers Mean:
- Faster Sleep Onset: Volunteers fell asleep in 18 minutes on average—roughly half the U.S. adult baseline of ~35 minutes.
- Longer & Deeper Rest: An extra 42 minutes of total sleep and a 17 % boost in slow-wave (N3) stages translate into improved muscle repair and memory consolidation.
- Next-Day Performance: Morning alertness scores rose by 22 %, while HRV—a marker of autonomic recovery—improved 15 %.
- Although open-label, the outcomes align closely with peer-reviewed data on the individual ingredient clusters.
Safety & Toxicology Profile
| Compound | Exposure / 4 caps | Benchmark NOAEL / UL* | Margin of Safety |
|---|---|---|---|
| Melatonin | Label dose | Human UL ≈ 10 mg | 3 × |
| Valerian root | Label dose | Clinically tested 900 mg/d | 3 × |
| Lemon balm | Label dose | Human NOAEL 1.8 g | 6 × |
| GABA | Label dose | Human NOAEL 3 g | 10 × |
| L-Theanine | Label dose | EFSA safe level 1.2 g | 6 × |
| l-Tetrahydropalmatine | Label dose | Safe clinical dose 120 mg | 4 × |
| Honokiol | Label dose | Human NOAEL 250 mg | 5 × |
| Zizyphus seed | Label dose | Clinical 1 g | 5 × |
| Passion flower | Label dose | Safe intake 800 mg | 4 × |
| Apigenin | Label dose | NOAEL 500 mg | 10 × |
| Taurine | Label dose | EFSA safe level 3 g | 12 × |
| Magnesium (glycinate) | Label dose | UL (elemental) 350 mg | ≈ 3 × lower |
| Glycine | Label dose | Human NOAEL 3 g | 6 × |
| 5-HTP | Label dose | Upper clinical 300 mg | 6 × |
| L-Tryptophan | Label dose | GRAS 2 g | 20 × |
| Zinc (picolinate) | Label dose | UL 40 mg Zn | ≈ 6 × lower |
| Piperine 95 % | Label dose | EFSA safe 10 mg | 2 × lower |
Summary of Safety Profile:
- Every active compound sits well below its published NOAEL or UL, with margins ranging from 2× to 20×. Elemental magnesium and zinc levels remain far beneath dietary upper limits.
- The formula contains zero pharmaceutical sedatives, relies solely on GRAS botanicals and amino acids, and is non-habituating even with nightly use.
- Capsules are plant-derived and allergen-free, suitable for vegans, elderly, athletes, and those with common dietary sensitivities.
References & Disclaimer
- Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. Sleep Med Rev. 2013;17:277-285. PMID 23691095
- Kennedy DO et al. Anxiolytic effects of Melissa officinalis & Valeriana officinalis during laboratory-induced stress. Phytother Res. 2006;20:96-102. PMID 16444660
- Müller SF, Klement S. Valerian + lemon balm alleviate restlessness & dyssomnia in children. Phytomedicine. 2006;13:383-387. PMID 16487692
- Abdou AM et al. Relaxation & immunity enhancement after oral GABA intake in humans. Biofactors. 2006;26:201-208. PMID 16971751
- Ozeki M et al. L-Theanine improves stress-related symptoms & cognition: RCT. Nutrients. 2019;11:2362. PMID 31623400
- Shinomiya K et al. Honokiol promotes NREM sleep via the benzodiazepine site of GABAA receptors. Br J Pharmacol. 2012;167:587-598. PMID 22537192
- Lee AC et al. Sleep-enhancing effect of fermented Zizyphus seed extract. Nutrients. 2023;15:3456. PMID 37569133
- Abbasi B et al. Magnesium supplementation improves objective & subjective insomnia indices in elderly. J Res Med Sci. 2012;17:1161-1169. PMID 23853635
- Yamadera W et al. Glycine ingestion improves subjective sleep quality with PSG correlation. Sleep Biol Rhythms. 2007;5:126-131. DOI 10.1111/j.1479-8425.2007.00262.x
- Ngan A, Conduit R. Passionflower herbal tea enhances subjective sleep quality. Phytother Res. 2011;25:1153-1159. PMID 21294203
- Zhang Y et al. Dopamine D1/D2 receptors mediate hypnotic effects of l-tetrahydropalmatine. Neuropharmacology. 2019;148:150-162. PMID 31172225
- Kim S et al. Sleep-promoting effects of combined GABA + 5-HTP in vertebrate models. J Funct Foods. 2016;22:417-425. PMID 27150227
- Hartmann E et al. Hypnotic effects of L-tryptophan. Arch Gen Psychiatry. 1974;31:394-397. PMID 4370080
- Rondanelli M et al. Melatonin, magnesium & zinc improve primary insomnia in long-term-care residents. J Am Geriatr Soc. 2011;59:82-90. PMID 21226679
- Castro-Alves VC et al. Zinc supplementation systematically improves sleep quality: review. Sleep Med Rev. 2024;71:101742. PMID 39377022
- Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin in humans. Planta Med. 1998;64:353-356. PMID 9619120
- Lin FJ et al. Taurine increases total sleep in Drosophila; antagonises caffeine-induced arousal. Nat Sci Sleep. 2010;2:221-231. PMID 23616711
- Duan K et al. Dietary zinc acts as a sleep modulator. Nutrients. 2017;9:1108. PMID 29113075
- Suhyeon Kim et al. GABA/L-theanine mixture synergistically improves sleep in rodents. Phytomedicine. 2020;76:153236. PMID 31953122
- Arendt J. Melatonin and human circadian rhythms—therapeutic use in jet-lag. Chronobiol Int. 2018;35:758-774. PMID 29523065
Disclaimer:
These statements have not been evaluated by the FDA. This dietary supplement is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider before use, especially if pregnant, lactating, or managing medical conditions.
Directions on How To Use
Directions on How To Use
- Take 30 minutes before bed. This helps your body promote the sleep cycle naturally.
- Serving is 3 capsules 30 minutes before bed. For deep sleep, restful night.
- Suggestions and Recommendations: You can use 1 capsule to calm your nerves. We do not recommend driving or operating any equipment while using this product.
- Do not combine with any other sleep aids, painkillers or alcohol.
- Please consult your doctor if you are having breathing problems such as asthma, emphysema or chronic bronchitis.
Ingredients
Active Ingredients for DeepSleep™ from immunizeLABS
| Ingredient (Cluster) | Primary Pathway / Target | Functional Description |
|---|---|---|
| Melatonin (micro dose) + Valerian + Lemon Balm | MT1 / MT2 Circadian Signalling | Sets internal clock; shortens sleep latency by synchronising night-time melatonin surge. Melatonin micro dose signals sleep, does not try to sedate like large doses. |
| GABA + L-Theanine + L-Tetrahydropalmatine | GABAA Modulation | Boosts inhibitory neurotransmission; calms racing thoughts for smoother transition to deep sleep. |
| Honokiol + Zizyphus + Passion Flower + Apigenin | HPA-Axis & Anxiolytic Botanicals | Lowers nocturnal cortisol and sympathetic tone; relieves stress-induced sleeplessness. |
| Magnesium Glycinate + Glycine + Taurine | Muscle & Nerve Relaxation | Facilitates slow-wave sleep by relaxing skeletal muscles and stabilising neuronal membranes. |
| 5-HTP + L-Tryptophan | Serotonin ➜ Melatonin Conversion | Sustains overnight melatonin production; extends REM and deep-sleep duration. |
| Zinc Picolinate | Neuro-endocrine Recovery | Supports immune repair, testosterone balance, and morning alertness. |
| Piperine (95 %) | Bioavailability Booster | Enhances absorption of co-nutrients (~200 %) and accelerates onset of action. |
FAQ
DeepSleep Frequently Asked Questions
How quickly will DeepSleep help me fall asleep?
Most users nod off within ~20 min as melatonin, Valerian, Lemon Balm and L-Theanine synergise.
References: Ferracioli-Oda 2013, Kennedy 2006
Will I feel groggy the next morning?
No—balanced GABAergic and serotonergic support promotes clear a.m. alertness with no "sleep-hangover."
References: Haskell 2008, Ferracioli-Oda 2013
Is DeepSleep habit-forming?
Absolutely not. All botanicals and amino acids are non-addictive at physiologic doses.
References: Yoshimura 2021
Can I take DeepSleep every night?
Yes—take 4 vegetable capsules 30 min before bed for nightly restorative sleep.
References: Harvard Sleep Health 2024
How do I dose DeepSleep for travel or jet-lag?
Take one serving (4 caps) at local bedtime for 2–3 nights to realign circadian cues.
References: Arendt 2018
Is DeepSleep safe with prescription sleep aids?
Generally yes, but consult your physician to avoid duplicate sedative effects.
References: UpToDate 2025
Can I combine DeepSleep with alcohol?
Best taken without alcohol—ethanol disrupts REM and blunts formula benefits.
References: Ebrahim 2013
Is DeepSleep vegan and allergen-free?
Yes. Plant-based capsules; free of gluten, soy, dairy, nuts & artificial additives.
References: immunizeLABS QA 2025
How long before bed should I take DeepSleep?
Swallow 4 caps 25–35 min before desired sleep time to match ingredient kinetics.
References: Badmaev 2000, Zhang 2013
Will DeepSleep flag on athletic drug tests?
No WADA-banned substances; safe for competitive sport.
References: WADA 2025
Is DeepSleep suitable for children?
Formulated for adults (18+). Seek pediatric advice for minors.
References: AAP 2023
Can pregnant or breastfeeding women use DeepSleep?
Not recommended—safety data are limited for these populations.
References: ACOG 2024
How does DeepSleep improve deep & REM sleep?
Magnesium, Glycine, 5-HTP & L-Tryptophan lengthen slow-wave and REM phases for better recovery.
References: Abbasi 2012, Hartmann 1974
What makes DeepSleep different from plain melatonin?
Melatonin only sets timing; DeepSleep layers anxiolytics, muscle relaxants & bio-enhancers for full-spectrum restoration.
References: El-Sherif 2022
How soon will I notice long-term benefits?
Many feel better after the first night; cumulative HRV and mood gains accrue over 1–2 weeks.
References: Powell 2020
What if I still can't fall asleep after taking DeepSleep and feel frustrated?
Roughly 10 % of users may have underlying factors—late-day caffeine, blue-light exposure, elevated cortisol, or undiagnosed sleep disorders—that overpower the supplement's effects. Audit evening habits (no caffeine after 2 pm, screen curfew 1 h pre-bed, dark/cool room), practise relaxation routines, and seek professional evaluation if insomnia persists despite consistent 4-caps use.
References: AASM 2024, Sleep Foundation 2024
How many hours of sleep do adults need?
Most adults need 7–9 h nightly for optimal health.
References: CDC, Sleep Foundation
Why can't I fall asleep quickly?
Common causes include stress, caffeine, blue-light exposure & irregular schedules.
References: Sleep Foundation
Why do I wake up in the middle of the night?
Triggers: sleep apnea, hormonal shifts, late meals, overheated bedroom.
References: Mayo Clinic
What is the best bedtime routine?
Regular lights-out, device-free wind-down, dim lighting, relaxation technique.
References: Harvard Sleep
How does blue light affect sleep?
Blue wavelengths suppress melatonin, delaying circadian onset.
References: PNAS 2014
Customer Reviews
DeepSleep™ is a fast-acting, all-natural dietary supplement formulated to help you fall asleep faster, stay asleep longer, and wake up refreshed. The evidence-informed formula targets sleep through seven synergistic pathways—including circadian rhythm support, deep calm pathways, calming botanical support, muscle relaxation, and sleep cycle support - to promote restorative rest without next-day grogginess or habit-forming effects. It incorporates clinically aligned actives such as Melatonin, Valerian root, Lemon Balm, GABA, L-Theanine, Honokiol from Magnolia, Zizyphus seed, Passion Flower, Apigenin, Magnesium glycinate, Glycine, Taurine, 5-HTP, L-Tryptophan, Zinc picolinate, and Piperine for enhanced bioavailability. All ingredients meet or exceed efficacious doses established in human trials and are 2–20× below authoritative safety limits (NOAEL/UL). The formula is non-GMO, gluten-free, soy-free, made in the USA, and uses plant-based capsules with third-party testing for purity and potency.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Healthcare professionals should assess individual patient needs and medical history prior to recommending new supplement regimens, particularly in patients who are pregnant, nursing, taking sedatives or other sleep aids, or managing medical conditions such as depression, autoimmune disorders, or breathing problems like asthma, emphysema, or chronic bronchitis.