We don't rely on just one ingredient to keep pain free

• Inhibition of cyclooxygenase (COX) enzymes reducing prostaglandin production and inflammation.
• Modulation of ion channels to decrease neuronal firing and peripheral sensitization.
• Suppression of pro-inflammatory cytokines to reduce inflammation and pain signaling.
• Activation of endogenous opioid pathways, stimulating natural pain-relieving compounds in the body.
• Inhibition of p38-MAPK and JNK signaling pathways, which regulate pain sensitization.
• Enhancement of GABAergic and glycinergic inhibitory neurotransmission to reduce pain signal transmission.
• Activation of the endocannabinoid system to modulate pain perception.
• Upregulation of anti-inflammatory factors which inhibits production of nociceptive cytokines.
• Modulation of neurotransmitter release to reduce ATP-induced inflammation.
• Activation of descending pain inhibitory pathways in the central nervous system, involving biogenic amines like serotonin and norepinephrine.

Bromelain - Proteolytic enzyme that reduces inflammation by breaking down pro-inflammatory proteins. Enhances absorption of other ingredients like curcumin and boswellia.

Cissus Quadrangularis - Supports bone and joint health, reduces inflammation, and accelerates tissue repair. Synergizes with MSM and magnesium malate for musculoskeletal pain relief.

Curcumin - The natural anti-inflammatory pain reliever and Tylenol alternative. According to PubMed.gov, Curcumin matches the effectiveness of some anti-inflammatory drugs like NSAID without the side effects.

DLPA - Combines D-phenylalanine (blocks pain signals) and L-phenylalanine (supports neurotransmitter production). Effective for chronic pain management without drowsiness.

Ecklonia Cava Extract - Blocks COX-2 and LOX pathways, reducing inflammatory mediators and pain signals. Synergizes with curcumin and boswellia for enhanced anti-inflammatory effects.

Huperzine A - Inhibits acetylcholinesterase, increasing acetylcholine levels and modulating pain perception in the CNS. Works synergistically with L-THP and magnolia bark.

Corydalis Yanhusuo (L-Tetrahydropalmatine) - Possess analgesic and anti-inflammatory properties, promotes cardiovascular health, improves mood and reduces stress and anxiety. Modulates dopamine and serotonin pathways, reducing neuropathic pain and promoting relaxation without sedation. Works synergistically with DLPA and magnolia bark.

Magnolia Bark - A very effective analgesic and anti-inflammatory used for inflammatory arthritis, as well as spasmodic, migratory pain with edema. Contains honokiol and magnolol, which reduce inflammation and oxidative stress. Promotes relaxation without drowsiness. Synergizes with L-THP and curcumin.

MSM - Sulfur donor that supports joint health and reduces inflammation. Enhances the effects of cissus quadrangularis and bromelain.

N-Acetyl Cysteine - Endocannabinoid-like compound that reduces pain and inflammation by modulating mast cells and glial cells. Effective for nerve pain and chronic inflammatory conditions.

PEA - Anti-inflammatory flavonoid that stabilizes mast cells and reduces histamine release. Works synergistically with curcumin and boswellia.

Quercetin - Quercetin alleviates pain by suppressing neuroinflammation and oxidative stress through inhibition of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and modulation of GABAergic and opioidergic systems, while enhancing antioxidant defenses via Nrf2 pathway activation124. This flavonoid demonstrates efficacy across neuropathic, inflammatory, and cancer pain models by targeting multiple pathways simultaneously, offering non-opioid analgesia without tolerance development or addictive potential.

Rhein- Rhein alleviates pain by suppressing pro-inflammatory cytokines like TNF-α and IL-1β through inhibition of NF-κB signaling and P2X7 receptor antagonism, effectively reducing inflammation-driven nociception in conditions such as arthritis1357. Additionally, it mitigates cartilage degradation by downregulating matrix metalloproteinases while enhancing endogenous opioid pathways indirectly through reduced inflammatory signaling, offering analgesic benefits without the gastrointestinal risks associated with conventional NSAIDs.

Willow Bark - The pain relieving and anti-inflammatory properties of willow bark (Salix alba) are so powerful that it is sometimes referred to as "nature's aspirin." Willow bark contains salicin and other compounds that work synergistically to reduce inflammation and pain by inhibiting pro-inflammatory cytokines, COX-2 enzymes, and mediators like nuclear factor kappa B. Clinical studies have shown that willow bark extract can effectively alleviate various types of pain, including lower back pain and osteoarthritis, with higher doses providing more significant pain relief compared to lower doses or placebo.

Fulvic Acid -  Fulvic acid helps alleviate pain by suppressing pro-inflammatory cytokines like TNF-α and reducing the expression of COX-2 and prostaglandin E2, which are key mediators in the inflammatory pain response. Additionally, fulvic acid enhances the bioavailability of other ingredients by forming complexes with nutrients, improving their absorption across biological membranes and potentially increasing their efficacy, as demonstrated in studies showing increased uptake of compounds like carbamazepine when conjugated with fulvic acid.

Piperine -  Enhances bioavailability of curcumin, boswellia, and other lipophilic compounds. Included at a low dose to avoid gastrointestinal irritation.

Bromelain -  Proteolytic enzyme that reduces inflammation by breaking down pro-inflammatory proteins. Enhances absorption of other ingredients like curcumin and boswellia.

Vitamin C (Ascorbic Acid) -  Antioxidant that supports collagen synthesis and enhances immune function. Boosts the effects of MSM and cissus quadrangularis.

Please go to the Ingredients tab below for independent third party reports on efficacy of the ingredients

All our ingredients are of the highest quality and organic where possible

Each ingredient has references on efficacy below