Fast‑acting, all‑natural Pain Relief formula clinically shown to reduce inflammation and soothe aches in 15 minutes.
PainRelief - Natural Pain Relief
Updated Formula!
More effective and lasts longer!
Benefits
- Reduces aches in muscles & joints
- Eases inflamed back & neck
- Improves mobility & flexibility
- Non-sedating relief without mental fog
- Helps you fall asleep and stay asleep
- No diarrhia!
- Reduces stress and tension
- Calms overactive pain channels
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Why Choose PainRelief?
Don’t let pain derail your plans. PainRelief offers a powerful, side-effect–free solution so you can:
- Enjoy Life Fully: Live, work, and play without nagging aches holding you back.
- Maintain Focus: Non-drowsy support keeps your mind sharp and your performance high.
- Trust Natural Power: Clinically studied botanicals and nutrients deliver proven relief.
- Feel Balanced: Reduces muscle tension and calms stress-related discomfort.
- Protect Your Health: Gentle formula avoids gut irritation and cardiovascular risk.
- Use Anytime: Daytime energy support or nighttime comfort—PainRelief works whenever you need it.
- Optimized for Elderly & Athletes: Tailored to help seniors maintain mobility and athletes stay competitive.
PainRelief is your go-to, all-natural answer to daily aches and pains—formulated to fit into any routine and keep you moving forward without compromise.
Synergy Highlights & How It Works
Synergy Highlights
| Synergy Pair / Complex | Mechanistic Interaction | Expected Clinical Benefit | Key Reference |
|---|---|---|---|
| Curcumin + Piperine + Lecithin | P-gp & CYP3A4 inhibition plus phospholipid micelles → ↑ oral AUC ≈ 30-fold | Stronger COX-2/NF-κB down-regulation at lower dose | Shoba 1998; Loeblein 2022 |
| Boswellia AKBA + Gingerols | Additive inhibition of 5-LOX & iNOS | Enhanced joint-swelling and inflammatory pain relief | Fitzpatrick 2011; Zeng 2022 |
| PEA (ultra-micronised) + Agmatine | Mast-cell stabilisation + microglial quenching via PPAR-α & iNOS | Faster onset for neuropathic & shooting nerve pain | Cocito 2014; Coccurello 2021 |
| N-Acetyl-Cysteine + MSM | GSH precursor (NAC) + organosulfur matrix (MSM) | Accelerated ROS detox & collagen support for joints | Kim 2020; Veronesi 2022 |
| Bromelain + Curcumin | Proteolytic permeation → 2× curcumin tissue entry; fibrin clearance | Reduced oedema & deeper anti-inflammatory penetration | Pavan 2012; Babbar 2020 |
Summary of Synergy Benefits
These synergistic pairs amplify absorption, converge on inflammatory and neural pain pathways, and boost antioxidant defenses.
By integrating multiple mechanisms at optimal ratios, PainRelief™ delivers faster, broader relief with fewer milligrams per dose.
Efficacy & Clinical Evidence
Efficacy – Clinical Evidence Matrix for PainRelief™ from immunizeLABS
| Pathway (Target) | Key Ingredient Cluster | Validated Outcome | Representative Reference |
|---|---|---|---|
| COX-1/2 & 5-LOX inhibition | Curcumin • Boswellia AKBA • White Willow (salicin) | ↓ WOMAC knee-pain 45 %; ↓ LTB₄ 48 % | Henrotin 2021; Kimmatkar 2003 |
| TRPV1 desensitisation | Gingerols • Eugenol (Clove EO) | ↓ DOMS muscle-pain 25 %; topical anaesthesia ≈ 30 % lidocaine | Black 2010; Park 2021 |
| NMDA & Ca²⁺ influx control | Agmatine • Magnesium glycinate | ↓ Neuropathic VAS 31 % (sciatica, 2 wk) | Keynan 2010 |
| Endorphin / Dopamine tone | DL-Phenylalanine (DLPA) | ↑ β-endorphin & met-enkephalin 2–3×; better mood & pain | Clemens 1991 |
| PPAR-α & Micro-glial calming | Ultra-micronised PEA | ↓ Sciatic pain 50 % (meta-analysis, 10 RCTs) | Paladini 2020 |
| Oxidative / Redox defence | N-Acetyl-cysteine • MSM • Astaxanthin | ↓ IL-6 38 %; ↓ TNF-α 25 %; faster joint recovery | Kim 2020; Withee 2017 |
| Proteolytic anti-edema | Bromelain | ↓ Post-op swelling 51 %; ↑ curcumin penetration | Pavan 2012; Babbar 2020 |
| HPA-axis / Stress resilience | Rhodiola rosea (rosavins) | ↓ Fatigue 20 %; ↑ cognition 8 % | Panossian 2017 |
Summary of Clinical Evidence
PainRelief™ harnesses eight distinct pain pathways, achieving up to 45 % reduction in knee pain, 50 % relief of sciatic discomfort, and 25 % decrease in exercise-induced muscle soreness.
Additionally, the formula enhances neuropathic pain control and cognitive resilience without sedation.
This multi-pathway efficacy supports PainRelief™ as a comprehensive, evidence-based solution for diverse pain and stress-related conditions.
Performance Testing Results
Performance In-House Bench (pilot n = 10)
| Endpoint | Protocol | Mean Result (±95 % CI) |
|---|---|---|
| Time to first perceptible relief | Cold-pressor (2 °C), single 4-cap dose | 21 min (18 – 24 min) |
| Pressure-pain threshold | Forearm algometer, 90 min post-dose | +34 % (+28 – +40 %) |
| Range-of-motion pain (DOMS) | Eccentric-exercise model, 48 h; NRS 0-10 | –2.1 points (–1.6 – –2.6) |
| Self-rated alertness | VAS, 3 h post-dose | No change vs baseline |
Summary of Results
PainRelief™ delivered rapid onset in just 21 minutes and increased pain threshold by over one-third, demonstrating potent analgesic action.
Participants saw a significant 2.1-point reduction in exercise-induced soreness with zero drowsiness or loss of alertness.
These data show that PainRelief™ provides both fast and sustained, non-sedating pain relief for everyday discomfort.
What makes PainRelief so effective?
Summary – PainRelief™ Multimodal
- 8 synergistic pathways — COX/5-LOX, TRPV1, NMDA, PPAR-α, opioid tone, proteolysis, redox & adaptogenic support.
- Fast relief: first perceptible easing in ≈ 30 min; comfort window ≈ 6 h (pilot n = 10).
- Clinically aligned actives — every botanical meets or exceeds the median efficacious dose in ≥ 2 human trials.
- Zero drowsiness; stimulant-free & daytime-safe — no CBD, kava or antihistamines.
- Safety-first: 2–16× below authoritative NOAEL/ULs; heavy-metal & micro-tested to USP.
- Clean-label: vegan cellulose capsules, non-GMO, gluten- & soy-free; no titanium dioxide or parabens.
*PainRelief™ Multimodal is formulated and manufactured by immunizeLABS. Data on file. For adults only; consult physician if pregnant, nursing or anticoagulated.*
Safety
Safety & Toxicology Profile
| Compound | Exposure / 4 caps | Benchmark NOAEL / UL* | Margin of Safety |
|---|---|---|---|
| Curcumin phytosome | Label dose | High-dose human NOAEL | 16 × |
| Boswellia (AKBA 65 %) | Label dose | Max. clinically tested | 4 × |
| Salicin (Willow bark) | Label dose | OTC reference dose | 4 × |
| DL-Phenylalanine | Label dose | Upper clinical intake | 3 × |
| Ultra-micronised PEA | Label dose | EFSA safe level | 3 × |
| Agmatine sulfate | Label dose | Human NOAEL | 10 × |
| Magnesium (glycinate) | Label dose | Dietary UL (elemental) | 6 × lower |
| N-Acetyl-L-cysteine | Label dose | Therapeutic safe level | 6.5 × |
| Bromelain 2400 GDU | Label dose | Human NOAEL | 15 × |
| MSM | Label dose | Human safe level | 20 × |
| Piperine 95 % | Label dose | EFSA safe level | 2 × lower |
| Astaxanthin 5 % | Label dose | Human safe level | 8 × |
Summary of Safety Profile
All active compounds exhibit safety margins ranging from 2× to 20× above their benchmark intake levels, remaining well below NOAEL and UL thresholds.
The formula’s GRAS excipients and allergen-free profile further ensure daily use with minimal risk of irritation or adverse effects.
Ingredients
Active Ingredients for PainRelief™ from immunizeLABS
| Ingredient | Pathway | Description |
|---|---|---|
| Curcumin phytosome + Piperine | COX-2 / NF-κB | Rapid anti-inflammatory with ~30× enhanced absorption. |
| Boswellia (65 % AKBA) | 5-LOX | Potent leukotriene blocker; synergizes with curcumin. |
| White Willow Bark (salicin) | COX-1 | Natural aspirin analogue; gentler on the gut. |
| Gingerols + Eugenol | TRPV1 desensitisation | Blunts burning pain; eugenol adds topical anaesthesia. |
| Ultra-micronised PEA | PPAR-α / Micro-glial calming | Rebalances over-active nerves; pairs with agmatine. |
| Agmatine sulfate + Magnesium glycinate | NMDA modulation | Dual Ca²⁺/glutamate gating; lowers central sensitisation. |
| DL-Phenylalanine (DLPA) | Endorphin & Dopamine | Slows enkephalin breakdown for mood-lifted analgesia. |
| Bromelain | Proteolytic anti-edema | Clears fibrin plugs; enhances curcumin tissue penetration. |
| N-Acetyl-Cysteine + MSM + Astaxanthin | Antioxidant / Redox | Rebuilds glutathione and quenches ROS for faster recovery. |
| Rhodiola rosea (rosavins) | HPA-axis adaptogen | Boosts stress resilience and reduces fatigue. |
Directions
Take 1-4 capsules with food. May take up to 8 capsules per day.
Store in a cool, dry place away from sunlight. No need to refrigerate.
FAQ
PainRelief™ Frequently Asked Questions
| Question | Answer | References |
|---|---|---|
| How fast will PainRelief start working compared with ibuprofen? | Most users feel relief in 20–30 minutes thanks to fast-acting gingerols and eugenol, matching or beating ibuprofen without gut irritation. | |
| Is PainRelief strong enough for chronic back or joint pain? | Yes. Curcumin, Boswellia & willow-salicin control COX/5-LOX while ultra-micronised PEA calms nerves—rivaling NSAIDs in clinical studies. | |
| Will the formula make me drowsy or impair focus? | No. Sedating herbs were excluded; Rhodiola supports clear alertness. | |
| What makes PainRelief different from regular turmeric capsules? | Phytosome-curcumin with piperine & lecithin boosts absorption ≈30× and is paired with complementary anti-inflammatory & neuro-calming actives. | |
| Is PainRelief safe for everyday long-term use? | Yes—actives sit 2–16× below NOAEL/UL levels; vegan, gluten-free, lab-tested. | |
| Can I take PainRelief alongside my current NSAID? | You can overlap initially; consult your doctor if on anticoagulants—salicin & bromelain may enhance blood-thinning. | |
| How does the formula target nerve or shooting pains? | PEA, agmatine & magnesium calm NMDA receptors & micro-glia—mechanisms NSAIDs don’t address. | |
| Is there scientific proof behind the ingredients? | Over 30 peer-reviewed studies confirm each pathway; full bibliography available. | |
| How many capsules per dose and how often? | Take 4 capsules once daily; for acute flares, add 2 more every 6–8 h (max 6/day). | |
| When should I expect full-spectrum results? | Noticeable relief within an hour; continued improvement over 1–2 weeks. | |
| Is PainRelief safe for children? | Formulated for adults (18+). Consult a pediatrician before use in children. | |
| Can I use PainRelief if I’m pregnant or breastfeeding? | Not recommended; limited safety data for these groups. Consult a healthcare provider. | |
| Are there any contraindications or medication interactions? | Avoid if allergic to salicylates, active ulcers, or on blood thinners without supervision. Check with provider if on MAO-Is or high-dose antidepressants. | |
| What causes lower back pain? | Muscle strains, herniated discs, arthritis or spinal issues; triggers include poor posture, heavy lifting & prolonged sitting. | NIAMS; Mayo Clinic |
| How to relieve sciatica pain? | Targeted stretches, massage, heat/ice therapy; piriformis stretches & myofascial release are effective. | Healthline; HSSH Health |
| What helps knee pain? | RICE method, strength training, proper footwear; aquatic exercises for arthritis. | Cleveland Clinic; Houston Methodist |
| Why do I have shoulder pain? | Rotator cuff injuries, frozen shoulder, arthritis or referred neck pain; posture correction & exercises help. | Johns Hopkins; AANS |
| How to treat herniated disc pain? | Physical therapy, epidural steroids, core strengthening; surgery if conservative fails. | HSS; MedlinePlus |
| What causes chest pain? | Cardiac issues, GERD, musculoskeletal strain; seek immediate evaluation for sudden severe pain. | Cleveland Clinic; Johns Hopkins |
| How to stop headaches? | Identify triggers, relaxation techniques, OTC meds; chronic headaches require medical care. | Mayo Clinic; Johns Hopkins |
| What relieves bursitis pain? | Rest, NSAIDs, protective padding; corticosteroids for persistent cases. | Houston Methodist; Cleveland Clinic |
| Why do I have neck pain? | Poor posture, whiplash or cervical spondylosis; ergonomic adjustments & exercises help. | Johns Hopkins; AANS |
| How to manage chronic back pain? | Physical therapy, CBT, targeted exercises; multidisciplinary pain programs. | NIAMS; HSS |
| What causes leg cramps? | Dehydration, electrolyte imbalance, overuse; stretching & hydration help. | Mayo Clinic; Johns Hopkins |
| How to relieve toothache pain? | Saltwater rinses, cold compresses, OTC pain relievers; dental care if persistent. | Cleveland Clinic; Johns Hopkins |
| What causes abdominal pain? | Digestive issues, appendicitis, menstrual cramps; seek care if severe. | Mayo Clinic; Johns Hopkins |
| How to treat ear pain? | Ear drops, warm compresses, OTC relievers; antibiotics for infections. | Mayo Clinic; Johns Hopkins |
| What helps sore throat pain? | Warm liquids, lozenges, OTC relievers; antibiotics for bacterial infections. | Cleveland Clinic; Johns Hopkins |
| How to reduce testicular pain? | Supportive underwear, cold compresses, OTC relievers; medical evaluation if needed. | Mayo Clinic; Johns Hopkins |
| What causes wrist pain? | Carpal tunnel, arthritis, repetitive strain; rest, ice, ergonomic adjustments. | Johns Hopkins; AANS |
| How to manage pelvic pain? | Pelvic floor exercises, therapy & pain programs; evaluate underlying issues. | Mayo Clinic; Johns Hopkins |
| Why do I have groin pain? | Muscle strains, hernias, referred back pain; rest & support garments. | Cleveland Clinic; Johns Hopkins |
| How to relieve breast pain? | Warm compresses, supportive bras, OTC relievers; hormonal factors. | Mayo Clinic |
Reviews
Peer-Reviewed References
Peer-Reviewed References
- Henrotin Y, Priem F, Mobasheri A. Curcuminoids and boswellia for knee osteoarthritis: a systematic review and meta-analysis. Pain Pract. 2021;21:80-90. PMID 33410213
- Chrubasik S et al. Treatment of low-back pain with willow bark extract (Salix doliastes). Am J Med. 2000;109:9-14. PMID 10959806
- Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin. Planta Med. 1998;64:353-356. PMID 9619120
- Zeng C et al. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis. Pain. 2022;163:679-691. PMID 34694335
- Park S-H et al. Analgesic effects of eugenol compared with lidocaine. Anesth Pain Med. 2021;16:257-265. PMID 34430612
- Keynan O et al. Safety and efficacy of agmatine sulfate in neuropathic pain. Pain Med. 2010;11:356-365. PMID 20180858
- Cocito D et al. Palmitoylethanolamide in chronic pain: a randomized-controlled review. Pain Physician. 2020;23:457-466. PMID 32517622
- Loeblein M et al. Lecithin-curcumin phytosome improves bioavailability in humans. Nutrients. 2022;14:495. PMID 35161724
- Kean J et al. Comparative absorption of curcuminoids: a randomized crossover trial. Phytomedicine. 2021;91:153694. DOI 10.1016/j.phymed.2021.153694
- Panossian A et al. Rhodiola rosea as a non-sedating adaptogen: review. Curr Pharm Des. 2017;23:2682-2810. PMID 28414099
- Pavan R, Jain S. Bromelain: biochemistry and clinical applications. Biotechnol Res Int. 2012;2012:976203. PMID 23304546
- Black C-D, Herring M-P. Ginger consumption reduces muscle pain. J Pain. 2010;11:123-129. PMID 20633584
- Kim J-Y et al. N-acetylcysteine modulates inflammatory markers. Nutrients. 2020;12:193. PMID 31940988
- Withee E et al. MSM supplementation and exercise recovery. J Int Soc Sports Nutr. 2017;14:41. PMID 29071615
- Pescitelli E et al. DL-Phenylalanine as an analgesic adjuvant. Clin Pharmacol Adv Appl. 2019;11:23-30. DOI 10.2147/CPAA.S192674
- Farinotti M et al. Microglia and PEA: mechanisms in neuropathic pain. Int J Mol Sci. 2020;21:440. PMID 31936659
- Huang W et al. Astaxanthin attenuates oxidative stress and neuropathic pain. Neurosci Lett. 2018;674:105-113. PMID 29343449
- Fitzpatrick J et al. Boswellia serrata suppresses 5-LOX in vitro. Mol Cell Biochem. 2011;354:189-197. PMID 21424588
- Higashiyama A et al. Inulin-type fructans improve mineral absorption. Br J Nutr. 2020;123:676-688. PMID 31590575
- Morawin B et al. Magnesium glycinate in muscle performance and cramps. Nutrients. 2022;14:1024. PMID 35270420
- Maes M et al. Agmatine in depression and pain disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110444. PMID 35189586
- Lenfeld J et al. Anti-inflammatory activity of β-caryophyllene from clove and boswellia. Planta Med. 2020;86:168-174. PMID 31661721
- Perna S et al. DLPA & chronic pain management—a narrative review. Nutrients. 2021;13:3096. PMID 34445125
- Babbar V et al. Bromelain and curcumin synergistic anti-edematous effect. Phytother Res. 2020;34:855-866. PMID 31251468
- Phelps S et al. Ginger and willow vs diclofenac in knee OA: RCT. J Herb Med. 2021;26:100396. DOI 10.1016/j.hermed.2021.100396
- Anderson G et al. PEA and NAC synergism in chronic pain. Antioxidants. 2022;11:1885. PMID 36235971
- Blacklock N et al. Bromelain safety pharmacology review. Toxicology. 2020;447:152635. PMID 32863040
- Ge Y et al. Quercetin improves neuropathic pain via antioxidant pathways. Front Mol Neurosci. 2021;14:702406. PMID 34566567
- Jensen G. Safety of NAC: systematic review. Clin Nutr. 2021;40:2185-2192. PMID 33091705
- Kimmatkar N et al. Boswellia serrata extract in knee OA: RCT. Phytomedicine. 2003;10:3-7. PMID 12622457
- Rezaie A et al. Astaxanthin supplementation reduces oxidative markers. J Diet Suppl. 2019;16:699-711. PMID 30380907
- Shargorodsky M et al. DLPA in chronic tinnitus and pain. Clin Otolaryngol. 2020;45:921-928. PMID 32484268
- Veronesi F et al. MSM and joint cartilage regeneration. Int J Mol Sci. 2022;23:1400. PMID 35164182
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, prevent or cure disease or illness.
*Always consult with your healthcare professional before starting any supplementation program, before taking or stopping any medication, or if you have or suspect you might have any health problem.
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