*** Now in capsules ***
PainRelief - Natural Pain Relief
|
Arthritis Pain Relief Muscle Pain Relief Fast Pain Relief Nerve Pain Relief Sciantica Pain Relief Chronic Pain Relief Joint Pain Relief Knee Pain Relief SI Joint Pain Relief Tendonitis Pain Relief Ankle Pain Relief | |
| | Increased Blood Circulation - Enhances blood circulation reducing pain and inflammation |
| | Anti-Inflammatory |
| | Antinociceptive- Reduces pain levels by blocking pain receptors |
| | Antispasmodic - Calms and reduces spasms |
| | Antioxidant- Reduces oxidative stress |
| | Lubricates Joints - Helps keep you limber and more flexible |
Sold out
In stock! Usually ships within 3-6 business days
WARNING: 40 million people in the US suffer from osteoarthritis , a degenerative joint disease. Most sufferers seek partial and temporary relief through nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, Motrin and Tylenol. Serious side effects of NSAIDs have has lead to gastrointestinal bleeding and ulceration, hypertension, congestive heart failure, edema and renal failure. Taking 2 aspirins a day increases your chances of kidney disease by 900 percent!
- 6,500 people die a year in the US alone from NSAIDS
- 103,000 people are seriously hospitalized every year in the US because of NSAIDs
- + Study Shows Long-term Use Of NSAIDs Causes Severe Intestinal Damage.pdf
There are better natural ways to reduce pain...
What makes PainRelief so effective?
We don't rely on just one ingredient to keep pain free
- Inhibition of cyclooxygenase (COX) enzymes reducing prostaglandin production and inflammation.
- Modulation of ion channels to decrease neuronal firing and peripheral sensitization.
- Suppression of pro-inflammatory cytokines to reduce inflammation and pain signaling.
- Activation of endogenous opioid pathways, stimulating natural pain-relieving compounds in the body.
- Inhibition of p38-MAPK and JNK signaling pathways, which regulate pain sensitization.
- Enhancement of GABAergic and glycinergic inhibitory neurotransmission to reduce pain signal transmission.
- Activation of the endocannabinoid system to modulate pain perception.
- Upregulation of anti-inflammatory factors which inhibits production of nociceptive cytokines.
- Modulation of neurotransmitter release to reduce ATP-induced inflammation.
- Activation of descending pain inhibitory pathways in the central nervous system, involving biogenic amines like serotonin and norepinephrine.
Boswellia Serrata - Anti-inflammatory compound that inhibits 5-lipoxygenase (5-LOX), reducing inflammation and pain in joints and soft tissues. Works synergistically with curcumin and quercetin.
Bromelain - Proteolytic enzyme that reduces inflammation by breaking down pro-inflammatory proteins. Enhances absorption of other ingredients like curcumin and boswellia.
Cissus Quadrangularis - Supports bone and joint health, reduces inflammation, and accelerates tissue repair. Synergizes with MSM and magnesium malate for musculoskeletal pain relief.
Curcumin - The natural anti-inflammatory pain reliever and Tylenol alternative. According to PubMed.gov, Curcumin matches the effectiveness of some anti-inflammatory drugs like NSAID without the side effects.
DLPA - Combines D-phenylalanine (blocks pain signals) and L-phenylalanine (supports neurotransmitter production). Effective for chronic pain management without drowsiness.
Ecklonia Cava Extract - Blocks COX-2 and LOX pathways, reducing inflammatory mediators and pain signals. Synergizes with curcumin and boswellia for enhanced anti-inflammatory effects.
Huperzine A - Inhibits acetylcholinesterase, increasing acetylcholine levels and modulating pain perception in the CNS. Works synergistically with L-THP and magnolia bark.
Corydalis Yanhusuo (L-Tetrahydropalmatine) - Possess analgesic and anti-inflammatory properties, promotes cardiovascular health, improves mood and reduces stress and anxiety. Modulates dopamine and serotonin pathways, reducing neuropathic pain and promoting relaxation without sedation. Works synergistically with DLPA and magnolia bark.
Magnolia Bark - A very effective analgesic and anti-inflammatory used for inflammatory arthritis, as well as spasmodic, migratory pain with edema. Contains honokiol and magnolol, which reduce inflammation and oxidative stress. Promotes relaxation without drowsiness. Synergizes with L-THP and curcumin.
MSM - Sulfur donor that supports joint health and reduces inflammation. Enhances the effects of cissus quadrangularis and bromelain.
N-Acetyl Cysteine - Endocannabinoid-like compound that reduces pain and inflammation by modulating mast cells and glial cells. Effective for nerve pain and chronic inflammatory conditions.
PEA - Anti-inflammatory flavonoid that stabilizes mast cells and reduces histamine release. Works synergistically with curcumin and boswellia.
Quercetin - Quercetin alleviates pain by suppressing neuroinflammation and oxidative stress through inhibition of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and modulation of GABAergic and opioidergic systems, while enhancing antioxidant defenses via Nrf2 pathway activation124. This flavonoid demonstrates efficacy across neuropathic, inflammatory, and cancer pain models by targeting multiple pathways simultaneously, offering non-opioid analgesia without tolerance development or addictive potential.
Rhein- Rhein alleviates pain by suppressing pro-inflammatory cytokines like TNF-α and IL-1β through inhibition of NF-κB signaling and P2X7 receptor antagonism, effectively reducing inflammation-driven nociception in conditions such as arthritis1357. Additionally, it mitigates cartilage degradation by downregulating matrix metalloproteinases while enhancing endogenous opioid pathways indirectly through reduced inflammatory signaling, offering analgesic benefits without the gastrointestinal risks associated with conventional NSAIDs.
Willow Bark - The pain relieving and anti-inflammatory properties of willow bark (Salix alba) are so powerful that it is sometimes referred to as "nature's aspirin." Willow bark contains salicin and other compounds that work synergistically to reduce inflammation and pain by inhibiting pro-inflammatory cytokines, COX-2 enzymes, and mediators like nuclear factor kappa B. Clinical studies have shown that willow bark extract can effectively alleviate various types of pain, including lower back pain and osteoarthritis, with higher doses providing more significant pain relief compared to lower doses or placebo.
Fulvic Acid - Fulvic acid helps alleviate pain by suppressing pro-inflammatory cytokines like TNF-α and reducing the expression of COX-2 and prostaglandin E2, which are key mediators in the inflammatory pain response. Additionally, fulvic acid enhances the bioavailability of other ingredients by forming complexes with nutrients, improving their absorption across biological membranes and potentially increasing their efficacy, as demonstrated in studies showing increased uptake of compounds like carbamazepine when conjugated with fulvic acid.
Piperine - Enhances bioavailability of curcumin, boswellia, and other lipophilic compounds. Included at a low dose to avoid gastrointestinal irritation.
Bromelain - Proteolytic enzyme that reduces inflammation by breaking down pro-inflammatory proteins. Enhances absorption of other ingredients like curcumin and boswellia.
Vitamin C (Ascorbic Acid) - Antioxidant that supports collagen synthesis and enhances immune function. Boosts the effects of MSM and cissus quadrangularis.
Please go to the Ingredients tab below for independent third party reports on efficacy of the ingredients
Reviews
Ingredients
All our ingredients are of the highest quality and organic where possible
Each ingredient has references on efficacy below
Boswellia Serrata - Anti-inflammatory properties helpful with rheumatoid arthritis, inflammatory bowel disease, and asthma. Studies have shown boswellia to be analgesic, anti-arthritic, anti-asthmatic, anti-fungal, anti-inflammatory, anti-tumor, cholesterol-lowering, and immunomodulating,
+ Treating pain pathways with boswellia herb.pdf
+ Boswellia Serrata A Potential Antiinflammatory Agent An Overview.pdf
Bromelain - Bromelain, a proteolytic enzyme complex from pineapple, exerts anti-inflammatory and analgesic effects by modulating the arachidonic acid pathway and reducing prostaglandin E2 production. It inhibits bradykinin and fibrin formation, reducing inflammation and edema. Bromelain also enhances the absorption of other compounds, potentially increasing their bioavailability and efficacy in pain management.
+ Potential role of bromelain in clinical and therapeutic applications.pdf
+ Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.pdf
Cissus Quadrangularis - Properties include analgesic , anti-inflammatory and antipyretic, anti-arthritic, bone healing and fighting fevers, preventing pain and supporting normal blood levels in diabetics. Cissus quadrangularis Linn inhibits prostaglandin production, interleukin one beta and decreases the production of reactive oxygen species promoting bone healing and reduced inflammation. The chondroprotective effects results in notable reduction in the reactive oxygen species' production that plays a central role in the cartilage destruction in osteoarthritic individuals.
+ Analgesic , anti-inflammatory and antipyretic activity of Cissus quadrangularis.pdf
+ Gastroprotective effect of Cissus quadrangularis.pdf
+ Pharmacological and therapeutic activity of Cissus quadrangularis An overview.pdf
+ iN VITRO ANTI-ARTHRITIC ACTIVITY OF CISSUS QUADRANGULARIS STEM EXTRACTpdf
+ Effect of cissus quadrangularis linn and zingiber officinale rosc in osteoarthritis patients.pdf
+ Herbal Treatment of Osteoarthritis A Hospital Based Clinical Study.pdf
Curcumin - Strongly anti-inflammatory. According to PubMed.gov, Curcumin matches the effectiveness of some anti-inflammatory drugs. If you are taking an NSAID, you are at approximately 3x greater risk for developing serious gastrointestinal side effects than those who aren't. Regular use of NSAID and analgesics like Tylenol is associated with significant, and very serious, side effects such as cardiovascular problems, gastrointestinal harm and kidney and/or liver damage. It is most effective for treating pain from fibromyalgia, sciatica and brachial nerve pain. It can also be useful for hepatic pain due to hepatitis and intestinal or gastric pain caused by diverticulitis, gastritis, gastric ulcers, IBD or IBS.
+ Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane).pdf
DLPA- DLPA combines two forms of phenylalanine to reduce pain and improve mood. The D-form inhibits the enzyme carboxypeptidase A, which intensifies pain signals, and blocks enkephalinase, preventing the breakdown of enkephalins (natural pain-killing substances). The L-form boosts mood-elevating neurotransmitters like dopamine and norepinephrine. DLPA may potentiate opiate analgesia, support the endogenous analgesia system, and provide relief for chronic pain conditions such as osteoarthritis and fibromyalgia.
+ Analgesic properties of enkephalinase inhibitors: animal and human studie
Ecklonia Cava Extract- Ecklonia cava extract exhibits potent anti-inflammatory effects by suppressing pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and inhibiting inflammatory mediators (NO, PGE2, COX-2). It modulates the NF-κB pathway and NLRP3 inflammasome activation, reducing pain signaling and inflammation in various models. The extract's phlorotannins, particularly 6,6′-bieckol and dieckol, demonstrate strong antioxidant activity, further contributing to its analgesic properties.
Huperzine A- Huperzine A exhibits analgesic effects through its action as an acetylcholinesterase inhibitor, enhancing cholinergic transmission and modulating pain pathways. It reduces inflammatory pain by suppressing pro-inflammatory cytokine production and attenuating neuroinflammation. Huperzine A also demonstrates neuroprotective properties and may enhance endogenous opioid signaling, contributing to its pain-relieving effects.
+ The pharmacology and therapeutic potential of (−)-huperzine A.pdf
L-Tetrahydropalmatine (from Corydalis Yanhusuo) - Used as a mild sedative, to relax spasms in the small intestine, mild depression, mild mental disorders, emotional disturbances, severe nerve damage, and limb tremors and to lower blood pressure.
+ L-Tetrahydropalamatine A Potential New Medication for the Treatment of Cocaine Addiction.pdf
+ The Antinociceptive Properties of the Corydalis yanhusuo Extract.pdf
Magnolia Bark - Effective analgesic and anti-inflammatory used for inflammatory arthritis, as well as spasmodic, migratory pain with edema.
MSM - Methylsulfonylmethane (MSM) reduces pain and inflammation by inhibiting NF-κB activation and decreasing the production of pro-inflammatory cytokines such as TNF-α and IL-6. It also exhibits antioxidant properties, scavenging reactive oxygen species and reducing oxidative stress-induced inflammation. MSM has been shown to improve joint health and reduce pain in osteoarthritis by modulating cartilage metabolism and reducing inflammatory markers.
+ Methylsulfonylmethane Applications and Safety of a Novel Dietary Supplement.pdf
N-Acetyl Cysteine (NAC) - Helps with pain and inflammation through multiple mechanisms. It acts as a powerful antioxidant, reducing oxidative stress and inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-612. NAC also modulates inflammation by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a key protein complex involved in inflammatory responses. Additionally, NAC activates mGlu2 receptors, which can inhibit the release of glutamate and other neurotransmitters involved in pain signaling, potentially leading to analgesic effects.
Palmitoylethanolamide (PEA) - PEA is a naturally occurring fatty acid amide that modulates pain and inflammation by activating peroxisome proliferator-activated receptor-alpha (PPAR-α), leading to the downregulation of pro-inflammatory mediators. It maintains cellular homeostasis by acting as a mediator in resolving inflammatory processes, influencing mast cells and microglia involved in neuroinflammation. PEA enhances the endocannabinoid system's function by increasing anandamide levels, thereby contributing to analgesic and anti-inflammatory effects.
+ Therapeutic Use of Palmitoylethanolamide as an Anti-Inflammatory and Immunomodulator.pdf
+ Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders.pdf
Quercetin - A flavonoid that exhibits anti-inflammatory properties by inhibiting the release of pro-inflammatory cytokines and mediators, thereby reducing inflammation and associated pain. Quercetin modulates signaling pathways, including the suppression of NF-κB activation, leading to decreased expression of inflammatory genes. Quercetin's antioxidant activity scavenges free radicals, mitigating oxidative stress and contributing to its analgesic effects.
+ Quercetin, Inflammation and Immunity.pdf
+ Quercetin a potential natural drug for adjuvant treatment of rheumatoid arthritis.pdf
+ The Emerging Role of Quercetin in the Treatment of Chronic Pain.pdf
Rhein - An anthraquinone derivative that , exhibits anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and enzymes, such as COX-2, thereby reducing pain and inflammation. Rhein suppresses the activation of the NF-κB pathway, leading to decreased expression of inflammatory mediators.
Rhein modulates signaling pathways involved in cartilage degradation, offering potential benefits in osteoarthritis management.
Willow Bark - The pain relieving and anti-inflammatory properties of willow bark (Salix alba) are so powerful that it is sometimes referred to as "nature's aspirin." Salacin, the main active ingredient in white willow bark, is the chemical from which aspirin’s main active ingredient (salicylic acid) is derived.
+ Pain Relief with a Proprietary Extract of Willow Bark in Rheumatology. An Open Trial..pdf
+Efficacy and Safety of White Willow Bark (Salix alba) Extracts.pdf
Fulvic Acid - Fulvic acid exhibits anti-inflammatory properties by modulating the release of pro-inflammatory cytokines, thereby aiding in the reduction of inflammation and associated pain. Fulvic acid enhances cellular signaling and nutrient absorption, contributing to improved cellular function and resilience against inflammatory stimuli. Fulvic acid's antioxidant capacity helps neutralize free radicals, reducing oxidative stress and its role in chronic inflammation.
+ Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes.pdf
+ Antioxidant activity of fulvic acid A living matter-derived bioactive compound.pdf
Piperine - Enhances bioavailability of curcumin, boswellia, and other lipophilic compounds. Included at a low dose to avoid gastrointestinal irritation. Piperine is an active alkaloid in black pepper that exhibits anti-inflammatory properties by inhibiting the production of pro-inflammatory mediators such as interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in stimulated human fibroblast-like synoviocytes. Studies have demonstrated that piperine can suppress the expression of matrix metalloproteinase-13 (MMP-13), an enzyme involved in cartilage degradation, thereby potentially alleviating symptoms associated with arthritis. Piperine's analgesic effects have been observed in animal models, where it increased pain tolerance in rats with induced hyperalgesia, suggesting its potential as a natural pain management agent. In humans, curcumin bioavailability increased by 2000% when administered with piperine.
+ Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.pdf
Vitamin C (Ascorbic Acid) - Vitamin C, a potent antioxidant, plays a crucial role in reducing inflammation by decreasing the levels of pro-inflammatory cytokines and oxidative stress markers, thereby aiding in the management of inflammatory conditions. Adequate vitamin C intake is essential for collagen synthesis, which supports joint and tissue health, potentially reducing pain associated with degenerative conditions like osteoarthritis. Vitamin C influences cellular signaling pathways, including the modulation of immune responses, which can help in controlling chronic inflammation and associated pain. Vitamin C may increase the bioavailability of MSM, potentially enhancing its therapeutic effects.
Directions
| Take 1-3 capsules on an empty stomach | |
| | Store in a cool, dry place away from sunlight. No need to refrigerate. |
Q & A
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, prevent or cure disease or illness.
*Always consult with your healthcare professional before starting any supplementation program, before taking or stopping any medication, or if you have or suspect you might have any health problem.
Our Promise To You
Organic ingredients where possible
No sugar, no gluten
No artificial ingredients
No harmful chemicals
Family owned business
Proudly made in the USA
Related Products
Boost Liposomal Glutathione - Mega Formula
Sold out
BreatheEasy Nasal Spray - Antiviral Nasal Spray
Sold out
Deep Sleep Formula - Delta Sleep
Sold out
FaceMiracle: Natural Anti-Aging Cream
Sold out
Healthy Digestion Formula A - No GERD, acid reflux, bloat, gas relief, silent reflux
Sold out