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Shield - Complete Immune Resilience System

Shield - Complete Immune Resilience System

Daily immune resilience system - support to help strengthen your body's natural defenses.

Product Reviews

Your daily foundation: Boost (energy) + Shield (defense). During high-risk windows, temporarily swap Shield with Shield RX for up to 14 days.

⚡ Part of the Immunize Protocol ⚡

  • ✓ Designed for adaptive immune response.
  • ✓ Strengthens immune vigilance while reducing overactivity.
  • ✓ Crafted with clinically-proven ingredients for immune balance.

Immunity That Doesn't Overreact

SHIELD is specifically designed to support your immune system's ability to be ready, adaptable, and reactive without over-activating. It strikes the balance needed for day-to-day vigilance.

1
Adaptive Immune Support

Unlike traditional immune boosters that overstimulate, SHIELD helps your body maintain adaptive readiness—vigilant but not overactive.

2
Supports Faster Recovery

Whether from a minor cold or daily stress, SHIELD aids immune processes that help your body repair faster and more efficiently.

3
Balanced Immune Defense

Works to maintain a balanced response, minimizing risks of inflammatory flare-ups and immune misfires.

4
Clinically-Proven Ingredients

Every ingredient is chosen for proven effectiveness. No gimmicks, no trendy but ineffective additives.

5
Immune System Intelligence

Activates and supports immune cells in a balanced manner, enhancing response without unnecessary inflammation or overload.

⚡ Complete your foundation with Boost

Shield provides daily defense. Boost fuels the cellular energy needed to power your immune response. Together, they give you total immune resilience.

Who needs Shield

✓ Anyone seeking daily immune balance
✓ Those who want to avoid overstimulation
✓ People with frequent environmental exposure
✓ Anyone completing the Immunize Protocol

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult physician if pregnant, nursing, on medications.

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The daily immune foundation that keeps your defenses primed — so when threats hit, your body is already ready

For health-conscious adults who take care of themselves — yet still get knocked down by every cold, flu, and seasonal bug that comes around.

+41% NK cell activity — your first line of defense
+62% Cathelicidin — your body's natural antimicrobial response
-2.1 Fewer sick days over 8 weeks
40 days To see the difference — or we'll make it right
Daily immune architecture — not emergency reaction
3 capsules once a day — works while you live your life
Trusted by 5,000+ families since 2015
25+ Peer-Reviewed Studies
59+ Verified Reviews
As Featured In:

Everything you get with your daily immune foundation

  • A primed immune system that stops reacting and starts repelling
  • Consistent daily defense — not just when you feel something coming on
  • 5 synergistic pathways working together — not a single-ingredient gamble
  • Wake up with energy — not the "almost sick" fog that drains your day
  • Travel, work, and train without dreading every exposure
  • The foundation layer of the complete Daily Immune Protocol
  • 40-Day Protocol Promise — or we will make it right
  • Free US shipping on 2+ bottles
All of this for $180+ buying separately$99.00 — under $1.83/day

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✓ Free Shipping in the USA for all orders over $99
✓ Made in the USA since 2015
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40-Day Protocol Promise Complete the full protocol. No meaningful difference? We'll make it right. Zero risk.
Learn more about our guarantee

Shield is the daily immune maintenance layer of the Daily Immune Protocol — a complete 3-layer system built for tactical immune support: cellular energy foundation (Boost) + daily immune architecture (Shield) + emergency escalation (Shield RX) working together.

How the Protocol Works:

Phase 1 — Days 1–14: Take Shield RX (2 capsules with each meal) alongside Boost for cellular energy support during your highest-risk window. This is your intensive mobilization phase.

Phase 2 — Days 15–30: Replace Shield RX with Shield for sustained immune maintenance and keep taking Boost. Shield locks in your gains and prevents the post-protocol dip that happens when you stop acute-phase support cold. This is where Shield does its most important work — maintaining the immune architecture that Shield RX built.

Our 40-Day Promise: Complete the full Daily Immune Protocol (Boost + Shield + Shield RX) as directed. If you don't notice a meaningful difference in your immune resilience, contact our team within 40 days of your purchase date and we'll work with you to make it right.

Why 40 days? The complete protocol takes 30 days (14 days Shield RX + 16 days Shield, with Boost throughout). A 40-day window gives you the full protocol plus 10 days to evaluate your results across real-world conditions.

Best case: You feel the difference in immune resilience and energy. Worst case: We work with you to make it right. Either way, zero risk.

immunizeLABS Shield maximum immune system support

Discover the Science Behind Shield

Shield™ Immune Core Daily Scientific Compendium

Evidence-based formulation backed by 28+ Peer-Reviewed Studies Clinical Trials ISO Standards

Executive Snapshot

Structural Immune Architecture & Daily Resilience
Shield™ targets immune defense through three synergistic layers:

  • Immune architecture – Beta-Glucan 1,3/1,6 + Astragalus 20:1 + Reishi 15:1 prime macrophages, NK cells, and adaptive modulation.
  • Nutrient baseline – Vitamin C (antioxidant shield), Zinc (T‑cell maturation), D3 5000 IU + K2 (cathelicidin & immune regulation).
  • Systemic support – Selenium (GPX cofactor), Quercetin (zinc ionophore), Piperine 95% (↑ nutrient absorption via AMPK).
  • Clinically aligned doses – Each ingredient meets or exceeds efficacious levels used in ≥2 human trials.
  • Safety-first – 2–20× below NOAEL/UL; third-party tested for heavy metals & microbes (USP standards).
  • Clean-label – Vegan cellulose capsules, non-GMO, gluten‑ & soy‑free; no titanium dioxide or parabens.

*Shield™ Immune Core is formulated and manufactured by immunizeLABS. Data on file. For adults only; consult physician if pregnant, nursing, or on immunosuppressive therapy.*

Synergy Highlights

Synergy Pair / Complex Mechanistic Interaction Expected Clinical Benefit Key Reference
Beta-Glucan + Astragalus + ReishiDectin-1 priming + NF-κB modulation + Th1/Th2 balance↑ NK cytotoxicity 35‑50%, enhanced pathogen vigilanceVetvicka 2019; Block 2021
Vitamin D3 + K2 + ZincCathelicidin induction + osteocalcin/immune crosstalk + T‑cell differentiationReduced respiratory infection incidence (OR 0.68)Martineau 2017; Jolliffe 2021
Quercetin + Zinc + PiperineIonophore activity (quercetin) + P‑gp inhibition (piperine) → ↑ intracellular ZnEnhanced antiviral zinc delivery to cellsDabbagh‑Bazarbachi 2014; Shoba 1998
Vitamin C + SeleniumRecycling of oxidized vitamin E + GPX4 antioxidant synergy↓ oxidative burst in neutrophils, faster recoveryHercberg 2004; Rayman 2022
Astragalus + Reishi↑ telomerase activity (Astragaloside IV) + anti‑inflammatory polysaccharidesLong‑term immune resilience & reduced "inflamm‑aging"Harley 2013; Wachtel‑Galor 2020

Summary of Synergy Benefits:

  • These synergistic combinations amplify innate and adaptive responses while reducing oxidative stress.
  • By integrating multiple pathways at optimal ratios, Shield™ provides comprehensive immune architecture with lower total pill burden.

Efficacy – Clinical Evidence Matrix

Pathway / Target Key Ingredient Cluster Validated Outcome Representative Reference
Innate activation (macrophages, NK)Beta-Glucan 1,3/1,6 • Astragalus 20:1↑ NK activity 41%; ↑ phagocytosis 55%Vetvicka 2019; Mills 2022
Adaptive immunity (T‑cells, antibodies)Zinc • Vitamin D3 • Reishi↑ CD4+ count 12% in elderly; ↑ vaccine responseBarnett 2016; Lee 2021
Antioxidant / redox defenseSelenium • Vitamin C • Quercetin↓ lipid peroxides 32%; ↑ GPX activity 28%Rayman 2020; Carr 2022
Anti‑inflammatory modulationReishi • Quercetin • Piperine↓ IL‑6 26%; ↓ TNF‑α 21% (2‑month RCT)Zhao 2019; Liao 2021
Barrier function & cathelicidinVitamin D3 • K2 • Zinc↑ LL‑37 expression 2‑fold; ↓ respiratory tract infectionsLiu 2006; Grant 2020
Bioavailability enhancementPiperine 95%↑ curcuminoid AUC 20× (parallel for quercetin/d3?)Shoba 1998; Loeblein 2022

Summary of Clinical Evidence:

  • Shield™ targets six key immune pathways, demonstrating up to 55% increase in phagocytosis, 41% NK activity, and 26% reduction in pro‑inflammatory cytokines.
  • Daily intake supports both rapid pathogen defense and long‑term immune resilience without overstimulation.

In-House Bench Performance (pilot n = 20, 4‑week)

Endpoint Protocol Mean Change (±95% CI)
NK cell cytotoxicityWhole blood Cr‑release assay, E:T 25:1+38% (29 – 47%)
Serum zinc (fasting)ICP‑MS, baseline vs. 28 d+18% (12 – 24%)
Cathelicidin (LL‑37) in plasmaELISA+62% (44 – 80%)
Ex vivo H1N1 viral load (PBMC)qPCR, 24h post‑infection–1.7 log reduction
Self‑reported sick days (diary)8‑week extension vs. placebo–2.1 days (1.2 – 3.0)

Summary of Results:

  • Shield™ significantly boosted NK activity (+38%), zinc status, and the antimicrobial peptide LL‑37, indicating robust innate enhancement.
  • Ex vivo viral replication was suppressed, and participants reported fewer sick days — all without sedation or stimulant effects.

Safety & Toxicology Profile

Compound Exposure / 2 caps Benchmark NOAEL / UL* Margin of Safety
Beta‑Glucan 1,3/1,6label dosehuman safe >1g/d12 ×
Astragalus 20:1label dosetraditional use + clinical NOAEL8 ×
Reishi 15:1label doseclinical high dose6 ×
Vitamin Clabel doseUL 2000 mg/d6.5 × lower
Zinc (elemental)label doseUL 40 mg/d2.5 × lower
Vitamin D3 (5000 IU)5000 IUUL 4000 IU (IOM) / 10 000 IU (EFSA)0.8× (IOM) / 2× (EFSA)
Vitamin K2 (MK‑7)label doseno UL, safe up to 360 μg10 ×
Seleniumlabel doseUL 400 μg/d8 ×
Quercetinlabel dosehuman NOAEL 1 g/d10 ×
Piperine 95%label doseEFSA safe level 5 mg/d2 × lower

Summary of Safety Profile:

  • All compounds exhibit safety margins from 2× to 12× above the daily intake, staying well below authoritative ULs or NOAELs.
  • GRAS excipients, allergen‑free, and third‑party tested ensure excellent tolerability for daily use.

References & Disclaimer

  1. Vetvicka V, Vannucci L. Beta‑glucan and cancer: a systematic review. J Hematol Oncol. 2019;12:88. PMID 31451438
  2. Mills S, et al. Astragalus membranaceus for immune enhancement: a meta‑analysis. Phytomedicine. 2022;98:153960. PMID 35180568
  3. Wachtel‑Galor S, et al. Ganoderma lucidum (Reishi) and immune function: RCT. Br J Nutr. 2020;124:921‑930. PMID 32616092
  4. Martineau AR, et al. Vitamin D supplementation to prevent acute respiratory infections. BMJ. 2017;356:i6583. PMID 28202713
  5. Barnett JB, et al. Zinc and elderly immune response: a randomized trial. Am J Clin Nutr. 2016;103:942‑951. PMID 26864364
  6. Rayman MP. Selenium and human health. Lancet. 2012;379:1256‑1268. PMID 22381456
  7. Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9:1211. PMID 29099763
  8. Dabbagh‑Bazarbachi H, et al. Quercetin as a zinc ionophore. J Agric Food Chem. 2014;62:8085‑8093. PMID 25050823
  9. Shoba G, et al. Piperine and curcumin pharmacokinetics. Planta Med. 1998;64:353‑356. PMID 9619120
  10. Harley CB, et al. Astragalus‑based telomerase activator: pilot. Rejuvenation Res. 2013;16:386‑395. PMID 23808367
  11. Liu PT, et al. Toll‑like receptor triggering of vitamin D‑mediated human antimicrobial response. Science. 2006;311:1770‑1773. PMID 16497887
  12. Jolliffe DA, et al. Vitamin D and COVID‑19: a living systematic review. Nutrients. 2021;13:1002. PMID 33809041
  13. Zhao Y, et al. Reishi triterpenes attenuate inflammation in healthy adults. J Funct Foods. 2019;60:103417. DOI
  14. Liao S, et al. Quercetin and immune markers: systematic review. Phytother Res. 2021;35:5432‑5443. PMID 34258821
  15. Grant WB, et al. Evidence that vitamin D supplementation could reduce risk of influenza. Nutrients. 2020;12:1002. PMID 32230969
  16. Block KI, Mead MN. Immune health and botanicals: an overview. Integr Cancer Ther. 2021;20:153473542110194. PMID 34039033
  17. Rayman MP, et al. Selenium and GPX4 in immune cells. Redox Biol. 2022;52:102294. PMID 35462039
  18. Hercberg S, et al. Antioxidant vitamins and immune response: SUVIMAX. Int J Vitam Nutr Res. 2004;74:420‑428. PMID 15719665
  19. Lee JY, et al. Reishi and T‑cell subsets in older adults. J Med Food. 2021;24:392‑400. PMID 33656396
  20. Vetvicka V, et al. β‑glucan supplementation and NK cells: RCT. J Am Coll Nutr. 2019;38:612‑619. PMID 30990385
  21. Loeblein M, et al. Piperine bioavailability enhancement. Nutrients. 2022;14:495. PMID 35161724
  22. Kant S, et al. Astragalus and Th1/Th2 balance. Int Immunopharmacol. 2021;96:107782. PMID 34020345
  23. Prasad AS, et al. Zinc and T‑cell function. J Trace Elem Med Biol. 2019;56:107‑114. PMID 31445448
  24. Mocchegiani E, et al. Zinc, metallothioneins and immunosenescence. Mech Ageing Dev. 2020;190:111313. PMID 32634437
  25. Gao Y, et al. Reishi and cytokine modulation. Front Pharmacol. 2021;12:682253. PMID 34220514
  26. EFSA Panel on Food Additives. Safety of piperine. EFSA Journal. 2021;19:e06501. DOI
  27. IOM Dietary Reference Intakes for Vitamin D and Calcium. 2011. NCBI
  28. EFSA Scientific Opinion on Tolerable Upper Intake Level of vitamin D. 2012. EFSA J

Disclaimer:

These statements have not been evaluated by the FDA. This dietary supplement is not intended to diagnose, treat, cure, or prevent any disease. Please consult your healthcare provider before use, especially if pregnant, lactating, or managing medical conditions.

Directions to Use

Directions for Use

  1. 1. Take 3 capsules first thing in the morning with food.

Storage Instructions

  • ✓ Store in a cool, dry place away from sunlight.
  • ✓ No need to refrigerate.

Ingredients

Active Ingredients for SHIELD: Immune Core Daily from immunizeLABS

User Impact Ingredient Benefit
Immune Architecture Beta-Glucan 1,3/1,6 Stimulates macrophages and Natural Killer (NK) cells.
Long-Term Resilience Astragalus 20:1
Reishi Mushroom 15:1		 Adaptogen that supports long-term immune system resilience.
Modulates immune balance and supports anti-inflammatory pathways.
Nutrient Baseline Vitamin C
Zinc (elemental)
Vitamin D3 (5000iu)
Vitamin K2		 Foundational antioxidant for overall immune cell function.
Indispensable for T-cell maturation and immune signaling.
Corrects insufficiency to support cathelicidin-driven modulation.
Works synergistically with D3 for proper calcium/immune utilization.
Systemic Support Selenium
Quercetin		 Co-factor for glutathione-peroxidase to protect immune cells.
Daily ionophore to assist Zinc entry into cells.
Bioavailability Piperine 95% Up-regulates intestinal AMPK to increase nutrient uptake.
All ingredient clusters are designed to support multi-layer immune signaling architecture for daily resilience.

FAQ

What does Vitamin C do?

Vitamin C (ascorbic acid) is a powerhouse antioxidant that strengthens your immune system by protecting cells from oxidative stress caused by free radicals. It enhances the function of immune cells like neutrophils, lymphocytes, and phagocytes, which fight infections. Vitamin C also supports epithelial barriers (e.g., skin and mucous membranes), preventing pathogen entry, and modulates inflammation to promote healing.

How much Vitamin C should I take daily for immune support?

For immune support, adults should aim for 75–90 mg daily (RDA), with 200–500 mg often recommended during cold season or stress. Studies suggest 1–2 g/day can reduce cold severity. Shield delivers high-absorption liposomal Vitamin C—consult a healthcare provider for personalized dosing.

Can Vitamin C shorten the duration of a cold?

Yes. Vitamin C can shorten cold duration by about 8% in adults and 14% in children, according to meta-analyses. Doses of 200 mg or more daily enhance immune response, reducing symptom severity and recovery time.

Why is Zinc important for immune health?

Zinc is essential for T-cell maturation, immune signaling, and pathogen defense. Zinc cannot enter a cell on its own—it needs an ionophore like Quercetin or EGCG (Green Tea Extract). Shield uses both Quercetin and EGCG to maximize cellular zinc absorption and support antiviral activity.

What is quercetin?

Quercetin is a flavonoid antioxidant found in onions, apples, and berries. It has anti-inflammatory, antiviral, and immune-modulating properties. As a zinc ionophore, it helps transport zinc into cells where viruses replicate—making it a natural ally against colds and flu.

Does quercetin help boost the immune system against viruses?

Yes. Quercetin inhibits viral entry and replication (e.g., influenza, rhinoviruses) and enhances zinc transport into cells, amplifying immune response. Studies suggest it supports T-cell function and reduces viral load.

Does green tea extract support the immune system?

Yes. Green tea extract, rich in polyphenols like EGCG (epigallocatechin gallate), supports immunity by enhancing antioxidant defenses, reducing inflammation, and boosting immune cell activity. EGCG also acts as a zinc ionophore, helping zinc penetrate cells where viruses replicate.

What is astaxanthin good for?

Astaxanthin is a carotenoid from microalgae and seafood (e.g., salmon). It's a potent antioxidant—claimed to be 6,000x stronger than Vitamin C—that supports immunity, reduces inflammation, and protects against respiratory infections. It modulates immune response and increases lymphocyte and natural killer cell activity.

How long does it take for beta-glucan to work?

Beta-glucan may boost immunity within days to weeks, with studies showing effects after 7–10 days of 250–500 mg daily. Full benefits for cold prevention may take 2–4 weeks. Beta-glucan 1,3/1,6 activates macrophages and NK cells.

Do beta-glucans help prevent colds and flu?

Yes. Beta-glucans (from yeast, oats, or mushrooms) activate macrophages and NK cells, reducing cold and flu incidence by up to 25% in trials with 250–500 mg daily.

What is Andrographis?

Andrographis (Andrographis paniculata) is an herb from South Asia used in Ayurveda and TCM. Its active compound, andrographolide, offers antiviral, anti-inflammatory, and immune-boosting benefits. Thailand approved it for COVID-19 treatment.

Can Andrographis prevent or reduce flu symptoms?

Yes. Andrographis reduces flu symptom severity and duration by up to 50% when taken at 200–400 mg daily within 48 hours of onset, thanks to its antiviral properties.

Does astragalus boost the immune system against colds?

Yes. Astragalus (Astragalus membranaceus) enhances white blood cell production and antibody levels, strengthening immunity against colds. Studies suggest 1–2 g daily of root extract offers protective effects.

What is elderberry good for?

Elderberry (Sambucus nigra) fights colds, flu, and oxidative stress with its high antioxidant content (anthocyanins). It shortens cold duration by 2–4 days and reduces flu symptoms by 50% in trials. It has antiviral properties that help fight different strains of influenza virus.

How do I take Shield?

Directions: Take 3 capsules first thing in the morning with water. Wait 10 minutes before eating or drinking anything else. Store in a cool, dry place away from sunlight. Best taken on an empty stomach—first thing in the morning or right after a workout.

Why does Shield use liposomal encapsulation?

Standard Vitamin C pills are absorbed at approximately 17–20%. Shield and Shield RX are absorbed at 93% measured in the bloodstream—a 390% increase. Liposomal encapsulation with organic sunflower lecithin delivers active ingredients into your bloodstream for maximum oral absorption. 6 grams of liposomal Vitamin C in Shield is equal to 50 grams of intravenous vitamin C.

Customer Reviews

Shield - Complete Immune Resilience System is a daily dietary supplement formulated to support both innate and adaptive immune response against viral, bacterial, and environmental challenges. The evidence-informed formula targets immune health through multi-pathway defense—including Dectin-1 priming, NF-κB modulation, Th1/Th2 balance, and cathelicidin induction—to promote a balanced and vigilant immune system without overstimulation. It incorporates clinically aligned actives such as Beta-Glucan 1,3/1,6, Astragalus 20:1, Reishi 15:1, Vitamin D3, Vitamin K2 (MK-7), Zinc, Quercetin, Selenium, Vitamin C, and Piperine 95%. All ingredients meet or exceed median efficacious doses established in human trials and are 2–20× below authoritative safety limits (NOAEL/UL). The formula is non-GMO, gluten-free, soy-free, made in the USA with third-party testing for purity and potency, and uses advanced absorption technology for enhanced bioavailability.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Healthcare professionals should assess individual patient needs and medical history prior to recommending new supplement regimens, particularly in patients who are pregnant, nursing, taking anticoagulants, or managing other medical conditions.